Comparing early and delayed parenteral nutrition after emergency abdominal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of early versus postponed supplementary parenteral nutrition in patients who have undergone emergency laparotomy. Participants will be randomized on the second postoperative day based on their calorie intake, with one group receiving parenteral nutrition immediately and the other starting it on the fifth postoperative day if their intake remains insufficient. The goal is to achieve a combined calorie intake of 70-80% of the calculated requirement through oral, enteral, and parenteral means. The study aims to determine the optimal timing for initiating parenteral nutrition to improve patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 18
* Emergency primary midline laparotomy or laparoscopy
* NRS-2002 (nutritional risk screening) score \< 7
* No contraindications for oral or enteral nutrition after surgery
* Unable to tolerate or take in at least 50% of calculated calorie requirement on postoperative day 2
* Capable of providing informed consent at the time of inclusion

Exclusion Criteria:

* Laparotomy without closure of the abdominal aponeurosis
* Laparoscopic appendectomy or cholecystectomy as the procedure
* Limiting mental or psychiatric disorders rendering participation unethical or unrealistic
* Patients with a very limited expected remaining time of living (\< 3 months)
* NRS-2002 = 7
* Pregnant or breastfeeding women
* Refusal to participate

Where it's running

• Herlev Hospital
  Herlev, Denmark Recruiting

Study contacts

• Principal investigator: Jannick B Hansen, M.D. — Copenhagen University Hospital at Herlev
• Study coordinator: Jannick B Hansen, M.D.
• Email: jannick.brander.hansen@regionh.dk
• Phone: +4538686862

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.