Comparing dry versus humidified incubators for sibling oocyte blastocyst development
Official title: Impact of Dry vs Humidified Culture Conditions on Blastocyst Development and Aneuploidy: A Time-lapse Sibling Oocyte Study
Run by ART Fertility Clinics LLC · NCT07270250 · Data updated 2026-11-12
This test checks whether keeping sibling eggs in a dry versus a humidified GERI time‑lapse incubator changes embryo development for people having PGT‑A with ICSI.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 43 Years |
| Sex | Women only |
| Enrollment | 60 (estimated) |
| Sponsor | ART Fertility Clinics LLC Academic / other |
| Locations | 1 site (Abu Dhabi, Abu Dhabi Emirate) |
| Status | Recruiting |
| Started | February 10, 2026 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | May 7, 2026 |
| Trial ID | NCT07270250 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people aged 18–43 undergoing PGT‑A with ICSI who expect multiple mature oocytes (≥4), have BMI <35, and will use fresh or frozen ejaculated sperm.
✕Probably not a fit
People using PGT‑M or PGT‑SR, those using testicular sperm, undergoing conventional IVF insemination, or with a history of fertilization failure are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional sibling‑oocyte study splits oocytes from the same cycle between dry and humidified chambers of a GERI time‑lapse incubator under continuous culture conditions. Embryos are monitored by time‑lapse imaging and cultured to blastocyst stage, with outcomes recorded such as total blastulation, blastocyst quality, biopsy rate, fertilization rate, and aneuploidy after PGT‑A. The design compares matched sibling oocytes to control for patient‑level factors and isolate the effect of incubation humidity. Results aim to inform whether one chamber type yields better developmental outcomes while supporting uninterrupted lab workflows.
Why it matters
Potential benefit: If successful, the trial could identify an incubation approach that improves blastocyst development and helps labs choose methods that may raise IVF success while streamlining workflow and costs.
How similar studies have gone: Some small reports suggest humidified continuous‑culture conditions may improve blastocyst development in no‑refresh systems, but existing data are limited and inconsistent.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * PGT-A cycles with more than at least 4 mature oocytes * ICSI * maternal age 18- 43 years old * PGT-A intended cycles with trophectoderm biopsies on day 5 /6/7 * patients with more than 8 oocytes expected for ICSI * BMI \<35 * fresh and frozen ejaculated sperm Exclusion Criteria: * PGT-M /PGT-SR cycles * fresh and frozen testicular sperm * IVF insemination * previous history of fertilization failure
Where it's running
-
ART Fertility Clinics LLC
Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates Recruiting
Study contacts
- Study coordinator: JONALYN EDADES, EMBA Healthcare Management
- Email: jonalyn.edades@artfertilityclinics.com
- Phone: +97126528000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.