Comparing distal and conventional radial access for complex heart procedures
Official title: DIStal Versus COnventional Radial Access for COMPLEX Large-bore Percutaneous Coronary Intervention (DISCO COMPLEX)
Run by University Hospital, Geneva · NCT05490238 · Data updated 2026-11-12
This study is testing if using a different access point in the wrist for heart procedures can make them safer and more effective for patients with complex coronary issues.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 708 (estimated) |
| Sponsor | University Hospital, Geneva Academic / other |
| Locations | 9 sites (Arlon and 8 other locations) |
| Status | Recruiting |
| Started | August 31, 2023 |
| Main results expected | May 1, 2027 |
| Study ends | June 1, 2027 |
| Registry record updated | October 15, 2026 |
| Trial ID | NCT05490238 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with complex coronary lesions requiring PCI, such as chronic total occlusions or heavily calcified lesions.
✕Probably not a fit
Patients with acute ST-segment elevation myocardial infarction or those with contraindications to transradial access will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the use of distal radial artery access as an alternative to conventional radial access for patients undergoing complex percutaneous coronary interventions (PCI). It aims to evaluate the feasibility and safety of using a specialized 7F guiding catheter in this context, particularly for challenging coronary lesions. The study is multicenter and observational, involving patients who meet specific criteria related to their coronary conditions. The goal is to determine if distal access can reduce complications and improve outcomes compared to traditional methods.
Why it matters
Potential benefit: If successful, this approach could lead to lower rates of vascular complications and improved outcomes for patients undergoing complex heart procedures.
How similar studies have gone: Previous studies have shown promising results with distal radial access, but this specific approach using a 7F guiding catheter is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years. * Patients presenting with CCS or ACS, including unstable angina or NSTEMI. * Patients planned for PCI of complex coronary lesions, such as CTO, left main coronary artery disease, heavily calcified lesions, complex bifurcations, or other complex coronary lesions in whom the operator anticipates that a 7F guiding catheter is indicated. * Patients able to provide written informed consent. Exclusion Criteria: * Patients with acute ST-segment elevation myocardial infarction. * Patients with cardiogenic shock. * Patients on chronic hemodialysis. * Patients with contraindications to TRA, such as occlusive upper arm peripheral artery disease, or known anatomic variants prohibiting TRA on both sides. * Patients with medical conditions that may cause non-compliance with the study protocol and/or may confound the data interpretation. * Patients unable to provide written informed consent.
Where it's running
-
Clinique St. Joseph Arlon - Groupe Vivalia
Arlon, Belgium Recruiting -
CHU Saint-Pierre
Brussels, Belgium Recruiting -
CHU de Charleroi
Charleroi, Belgium Recruiting -
Hôpital de La Louvière - Site Jolimont
La Louvière, Belgium Recruiting -
Agaplesion Bethesda Krankenhaus Bergedorf
Hamburg, Germany Recruiting -
Patras University Hospital
Pátrai, Greece Recruiting
Show 3 more locations
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Humanitas Research Hospital
Milan, Italy Recruiting -
Basel University Hospital
Basel, Basel, Switzerland Recruiting -
Geneva University Hospitals
Geneva, Canton of Geneva, Switzerland Recruiting
Study contacts
- Principal investigator: Juan F. Iglesias, MD — University Hospital, Geneva
- Study coordinator: Véronique Menoni
- Email: veronique.menoni@hug.ch
- Phone: +41795530516
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.