Comparing different toothpastes for treating white spot lesions on teeth
Clinical and Laboratory Effectiveness of Different Toothpastes in Treating White Spot Lesions
This study is testing three different types of toothpaste to see which one works best for treating white spots on teeth in teenagers who have just finished orthodontic treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 21 (estimated) |
| Ages | 12 Years to 18 Years |
| Sex | All |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Mansoura) |
| Trial ID | NCT06128434 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of three types of toothpaste—zinc-carbonated nano-hydroxyapatite, arginine, and fluoride—in treating white spot lesions (WSLs) that occur after orthodontic treatment. The study will utilize both in vivo and in vitro methodologies, including computerized image analysis and energy dispersive X-ray analysis, to assess changes in size and color of the lesions as well as remineralization. Participants aged 12-18 with post-orthodontic WSLs will be randomly assigned to different treatment groups over a six-month period.
Who should consider this trial
Good fit: Ideal candidates are patients aged 12-18 who have recently completed orthodontic treatment and have white spot lesions on their teeth.
Not a fit: Patients with cavitated enamel surfaces or those who have previously treated their white spot lesions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide effective treatment options for patients with white spot lesions, improving their dental aesthetics and health.
How similar studies have performed: Previous studies have shown varying degrees of success in treating white spot lesions with different remineralization agents, making this approach both relevant and promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Completion of fixed appliance therapy within the past 1 week. * Presence of at least one post-orthodontic white spot lesion on the labial surfaces of the six maxillary anterior teeth with a score of 1 or 2 on International Caries Detection and Assessment System (ICDAS II). Exclusion Criteria: * Previous or planned treatment of WSLs. * Cavitated enamel surface. * Teeth with any composite restorations, veneers, crowns. * Surface defects (developmental defects, fluorosis, intrinsic and extrinsic discolorations, etc.). * Smoking habits.
Where this trial is running
Mansoura
- Mansoura University — Mansoura, Egypt (Recruiting)
Study contacts
- Study coordinator: Masar Mohammed Fadhle, Master degree/ Lecturer
- Email: masar19h@gmail.com
- Phone: 01149192272
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.