Comparing different therapies for treating H. pylori infection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the efficacy and safety of various treatment regimens for Helicobacter pylori infection, including vonoprazan-based dual and triple therapies, bismuth quadruple therapy, and lansoprazole-based therapies. A total of 1200 adult participants with confirmed H. pylori infection will be randomly assigned to receive one of the treatment regimens for 14 days. The study will also investigate long-term effects on gut microbiota, antibiotic resistance, and metabolic parameters following treatment. The goal is to determine which therapy is most effective in eradicating the infection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients with naive H. pylori infection
2. Subjects with over 20 years old

Exclusion Criteria:

1. Younger than 20 years old
2. Ever received H. eradication therapy
3. ever received total or subtotal gastrectomy in the past
4. Severe chronic disease, such as end stage renal disease, liver cirrhosis, incurable malignant tumors
5. Women who are pregnant or breastfeeding
6. Those who are not suitable to receive study drugs: such as a history of allergies to study drugs or serious side effects, etc.
7. Patients with chronic hepatitis (AST or ALT \>40 IU/L)
8. Subjects who cannot sign informed consent by themselves

Where it's running

• National Taiwan University Hospital
  Taipei, Taiwan Recruiting

Study contacts

• Principal investigator: Jyh-Ming Liou, MD — National Taiwan University Hospital
• Study coordinator: Mei-Jyh Chen, MD
• Email: migichen@ntuh.gov.tw
• Phone: 88623123456

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Registry for managing Helicobacter pylori infection in Argentina

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• Eradicating H. Pylori with Argon Plasma During Endoscopy

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• Screening and treating H. pylori to prevent gastric cancer in young adults

  This study is testing if screening and treating young adults for H. pylori can help prevent gastric cancer in people aged 30-34 in several European countries.

  Recruiting at 6 sites University of Latvia · Zagreb, City of Zagreb and 6 other locations · NCT06275204

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.