Clinical trial Recruiting at 4 sites Observational Ages 18 and up

Comparing different surgical approaches for early-stage lung cancer treatment

Official title: Anatomical Segmentectomies for Early Stage Lung Cancer. A Multicenter Analysis of RATS, VATS and Open Approach

Run by Scientific Institute San Raffaele · NCT06737107 · Data updated 2026-11-12

This study looks at different types of surgery for early-stage lung cancer to see which method works best for patients.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment472 (estimated)
SponsorScientific Institute San Raffaele
Academic / other
Drugs / interventionschemotherapy
Locations4 sites (Rozzano, Milan and 3 other locations)
StatusRecruiting
StartedNovember 26, 2024
Main results expectedDecember 5, 2025
Study endsMay 31, 2026
Registry record updatedDecember 17, 2024
Trial IDNCT06737107 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults over 18 years old who have been diagnosed with non-small cell lung cancer and have undergone segmentectomy.

Probably not a fit

Patients under 18 years old or those diagnosed with conditions other than non-small cell lung cancer may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study analyzes the outcomes of robotic segmentectomies performed at four major medical centers, comparing them to video-assisted thoracoscopic surgery (VATS) and open surgical approaches. It aims to assess perioperative complications, surgery duration, lymph node dissection rates, and overall and disease-free survival across these techniques. The study includes patients diagnosed with non-small cell lung cancer (NSCLC) who underwent segmentectomies between January 2010 and December 2023. By evaluating these different surgical methods, the study seeks to provide insights into the most effective approaches for treating early-stage lung cancer.

Why it matters

Potential benefit: If successful, this study could lead to improved surgical outcomes and recovery for patients with early-stage lung cancer.

How similar studies have gone: Previous studies have shown promising results with robotic techniques in thoracic surgery, indicating potential for success in this comparative analysis.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Pre or post-operative diagnosis of NSCLC surgically treated with pulmonary segmentectomy from 1st January 2010 to the 31st to December 2023.
* Age \> then 18 years at the moment of surgery

Exclusion Criteria:

* Age \< then 18 years at the moment of surgery
* diagnosis other than NSCLC

Where it's running

  • Istituto Clinico Humanitas
    Rozzano, Milan, Italy
    Recruiting
  • Scientific Institute Ospedale San Raffaele
    Milan, Italy
    Recruiting
  • Istituto Europeo di Oncologia
    Milan, Italy
    Recruiting
  • Policlinico Universitario Agostino Gemelli
    Rome, Italy
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.