Comparing different solutions for pain relief and healing in dental treatments
Evaluation of the Effects of Different Irrigation Solutions Used in Regenerative Endodontic Treatment of Lower Molars With Open Necrotic Apexes on Postoperative Pain and Lesion Healing
This study tests which of three different cleaning solutions can help reduce pain and improve healing after dental treatments for certain damaged teeth.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 39 (estimated) |
| Ages | 8 Years to 15 Years |
| Sex | All |
| Sponsor | TC Erciyes University Academic / other |
| Locations | 1 site (Kayseri) |
| Trial ID | NCT06386991 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effects of three different irrigation solutions—EDTA, Etidronic Acid, and Citric Acid—on postoperative pain and healing in regenerative endodontic treatments for necrotic open apex molar teeth. The research involves cleaning and debriding the root canals of affected teeth and monitoring the healing process over a year. The goal is to determine which solution is most effective in promoting healing and reducing pain after treatment.
Who should consider this trial
Good fit: Ideal candidates are children aged 8-15 with molars that have an open apex and apical periodontitis, who do not have significant health issues.
Not a fit: Patients with systemic diseases, severe tooth damage, or those who have previously undergone root canal treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management and healing outcomes for patients undergoing regenerative endodontic treatments.
How similar studies have performed: While there have been studies on irrigation solutions in endodontics, this specific comparison of these three solutions in a pediatric population is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:• Molars with open apex * Teeth with apical periodontitis * Teeth for which prosthetic restoration is not planned * Patients between the ages of 8-15 who do not have any significant health problems * Patients who are not accompanied by periodontal problems and have good oral hygiene Exclusion Criteria:• People with systemic disease and allergic reactions * Severely damaged teeth * If the tooth has previously undergone root canal treatment. * Use of antibiotics, anti-inflammatory and painkillers in the last two weeks
Where this trial is running
Kayseri
- Erciyes Üniversitesi Diş Hekimliği Fakültesi — Kayseri, Turkey (Recruiting)
Study contacts
- Principal investigator: Eraslan Akyüz — Baş Araştirmaci
- Study coordinator: Eraslan Akyüz
- Email: ipekemamak@hotmail.com
- Phone: 4447138
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.