Comparing different monitors for measuring neuromuscular blockade during surgery
Comparative Assessment of Neuromuscular Blockade Monitors
University of Washington · NCT05006807
This study is testing different devices to see which one best measures how well neuromuscular blocking drugs work during surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | University of Washington (other) |
| Locations | 1 site (Seattle, Washington) |
| Trial ID | NCT05006807 on ClinicalTrials.gov |
What this trial studies
This research evaluates various laboratory-built and commercially available sensors that measure the effects of neuromuscular blocking drugs on neuromuscular function during surgery. The study compares mechanomyography, considered the gold standard, with other monitoring techniques like acceleromyography and electromyography. By measuring the evoked thumb twitch response to ulnar nerve stimulation, the study aims to assess the accuracy and reliability of these devices. Key endpoints include the train-of-four count, train-of-four ratio, and post tetanic count.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are undergoing anesthesia that requires neuromuscular blocking drugs.
Not a fit: Patients who are under 18 years old or undergoing procedures that do not require neuromuscular blocking drugs may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the accuracy of neuromuscular monitoring during surgeries, leading to better patient outcomes.
How similar studies have performed: Other studies have shown success with similar monitoring approaches, but this specific comparison of devices is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. 18 years of age or greater 2. Undergoing anesthesia that requires neuromuscular blocking drugs Exclusion criteria: 1. Less than 18 years of age 2. Undergoing anesthesia that does not require neuromuscular blocking drugs 3. Undergoing a procedure in which access to one or both arms is limited 4. Anatomical abnormalities of the hands or arms that preclude twitch monitoring with ulnar nerve stimulation and evoked thumb twitch response
Where this trial is running
Seattle, Washington
- University of Washington Medical Center — Seattle, Washington, United States (RECRUITING)
Study contacts
- Principal investigator: T. Andrew Bowdle, MD, PhD — University of Washington
- Study coordinator: Lisa Flint
- Email: lyflint@uw.edu
- Phone: 206 543-7817
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Neuromuscular Blockade