Comparing different methods for testing respiratory viruses
A Comparative Evaluation of Specimen Adequacy of a Traditional Nasopharyngeal Swab as Compared to Nasopharyngeal Saline Wash, Saliva, and Serum to Test for Respiratory Viruses and Antibody Response
NA · University of Nebraska · NCT05864118
This study is testing if new ways to collect samples, like using saliva or a gentle wash, can diagnose respiratory infections just as well as the traditional nose swab, while being easier and more comfortable for patients.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 1000 (estimated) |
| Ages | 19 Years and up |
| Sex | All |
| Sponsor | University of Nebraska (other) |
| Locations | 1 site (Omaha, Nebraska) |
| Trial ID | NCT05864118 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of two novel specimen collection methods—nasopharyngeal saline wash and saliva collection—against the traditional nasopharyngeal swab for diagnosing respiratory tract infections (RTIs). Given the invasive nature of nasopharyngeal swabbing, which can cause discomfort and lead to inadequate specimen procurement, the study aims to determine if the new methods can provide a less traumatic alternative for patients. Participants aged 19 and older presenting to the emergency department with a nasopharyngeal swab ordered will be included in the study. The outcomes will focus on the accuracy and patient experience associated with each collection method.
Who should consider this trial
Good fit: Ideal candidates are adults aged 19 years or older who are presenting to the emergency department with a nasopharyngeal swab ordered.
Not a fit: Patients who do not require testing for respiratory viruses or those under 19 years of age may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to less invasive and more patient-friendly methods for diagnosing respiratory infections.
How similar studies have performed: While the traditional nasopharyngeal swab method is well-established, the novel collection methods being tested are relatively new and have not been widely validated in previous studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 19 years or older presenting to the UNMC ED, or admitted from the UNMC ED with a non-research nasopharyngeal swab ordered. Exclusion Criteria: * None, if the inclusion criterion is met.
Where this trial is running
Omaha, Nebraska
- Thanh Nguyen — Omaha, Nebraska, United States (RECRUITING)
Study contacts
- Principal investigator: Thanh Nguyen, PhD — University of Nebraska
- Study coordinator: Thanh Nguyen, PhD
- Email: thang.nguyen@unmc.edu
- Phone: 402-559-7884
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Respiratory Tract Infections, Adenovirus, Coronavirus 229E, Coronavirus HKU1, Coronavirus NL63, Coronavirus OC43, Severe Acute Respiratory Syndrome Coronavirus 2, Human Metapneumovirus