Comparing different high-intensity interval training programs for heart rehabilitation

Efficacy of Prescription Methods for High-intensity Interval Training in Patients Enrolled in Outpatient Cardiac Rehabilitation

NA · Mayo Clinic · NCT04555512

This study is testing which of two different high-intensity workout programs helps people recovering from heart problems get fitter and feel better.

Quick facts

PhaseNA
Study typeInterventional
Enrollment30 (estimated)
Ages18 Years and up
SexAll
SponsorMayo Clinic (other)
Locations1 site (Rochester, Minnesota)
Trial IDNCT04555512 on ClinicalTrials.gov

What this trial studies

This study examines the effectiveness of two distinct high-intensity interval training (HIIT) approaches in improving fitness, heart function, and muscle oxygen uptake in patients undergoing cardiac rehabilitation. Participants will be assigned to either a Progressive High Intensity Interval Training (PRO-HIIT) or a Constant High Intensity Interval Training (CON-HIIT) regimen. The goal is to determine which training method yields better outcomes for patients recovering from cardiac events. The study will involve adult participants who meet specific eligibility criteria related to their cardiac condition.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older who are English-speaking and have a qualifying indication for non-surgical cardiac rehabilitation.

Not a fit: Patients who have undergone surgical interventions such as bypass surgery or heart transplants, or those unable to participate in high-intensity exercise, may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance cardiac rehabilitation programs, leading to improved recovery and quality of life for patients with heart conditions.

How similar studies have performed: Other studies have shown promising results with high-intensity interval training in cardiac rehabilitation, suggesting that this approach is both viable and beneficial.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adult 18 years and older.
* English speaking.
* Able to provide consent.
* Has a qualifying indication for center-based cardiac rehabilitation that is non-surgical (i.e., Acute coronary syndrome, myocardial infarction, percutaneous coronary intervention, and stable angina).

Exclusion Criteria:

* Participants referred to cardiac rehabilitation following coronary artery bypass surgery, heart valve repair/replacement, heart transplant, or those with ventricular assist devices.
* Patients who are unable to engage in a regularly structured exercise training program as part of a clinically indicated center-based outpatient cardiac rehabilitation program are not eligible.
* Patients unable/unwilling to provide informed consent will not be enrolled.
* Patients identified as having a contraindication to high intensity exercise.

Where this trial is running

Rochester, Minnesota

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Cardiac Rehabilitation

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.