Comparing different doses of triamcinolone for knee osteoarthritis pain relief

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the efficacy of three different doses of intra-articular triamcinolone acetonide (5mg, 10mg, and 40mg) in patients suffering from knee osteoarthritis. The study aims to determine the optimal dose that provides effective pain relief while minimizing potential side effects associated with corticosteroid injections. Participants will be assessed based on their knee pain levels and the severity of their osteoarthritis, following established criteria. The trial is designed to provide clearer guidance on corticosteroid dosing for knee osteoarthritis management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Symptomatic primary gonarthrosis of over 6 months duration (gonarthrosis according to the American College of Rheumatology criteria)
* Grade 1 to 3 Kellgren-Lawrence femorotibial osteoarthritis
* Knee pain provoked by activity over 4 and under 8 on 10 (Visual Analog Scale)

Exclusion Criteria:

* Bilateral symptomatic primary gonarthrosis
* Grade 4 Kellgren-Lawrence femorotibial osteoarthritis
* Isolated patellofemoral osteoarthritis
* Intra-articular corticosteroid infiltration to the knee within the past 3 months or chronic use of per os corticosteroid
* Intra-articular hyaluronic acid infiltration within the past 12 months.
* Intra-articular infiltration of platelet-rich plasma within the past 12 months.
* Disease affecting the study joint (systemic inflammatory disease, history of septic arthritis, osteonecrosis, etc.).
* Suspicion or presence of active local infectious process.
* Presence or suspicion of local neoplasia or metastasis
* Recent severe trauma to the knee (≤ 3 months)
* Significant cognitive impairment or inadequate language proficiency not allowing adequate response to study questionnaires
* Any other serious medical condition that does not allow participation in the study or may be a contraindication to cortisone injection

Where it's running

• Centre Hospitalier Universitaire de Montréal - Hôtel-Dieu
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Dien Hung Luong, MD — Centre hospitalier de l'Université de Montréal (CHUM)
• Study coordinator: Dien Hung Luong, MD
• Email: dh.luong79@gmail.com
• Phone: 5148908000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Tail Fat Application for Knee Osteoarthritis Pain and Stiffness

  This study tests whether applying sheep tail fat to the knee helps reduce pain and stiffness and improves daily activity in adults with gonarthrosis.

  Recruiting at 2 sites Inonu University · Bitlis and 1 other locations · NCT07867405

• Knee Osteoarthritis: See If Your Treatment Beliefs Help Your Physical Therapy

  This study will look to see if what patients expect from physical therapy influences the benefits they get for knee osteoarthritis.

  Recruiting Gazi University · Ankara, Yenimahalle · NCT07618403

• Oral vs IV Dexamethasone in Knee Replacement Recovery

  This real-world study compares how giving dexamethasone by mouth or by IV around knee replacement affects early pain, movement, and recovery.

  Recruiting Haseki Training and Research Hospital · Istanbul, Istanbul · NCT07442812

• Combined intra‑articular and peri‑articular PRP injections for chronic knee osteoarthritis

  This will test whether adding ultrasound-guided peri‑articular PRP injections to intra‑articular PRP helps adults 40–65 with moderate medial knee osteoarthritis have less pain and better function.

  Recruiting Ankara City Hospital Bilkent · Ankara, Çankaya · NCT07339137

• Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy for Older Adults with Knee Osteoarthritis

  This trial will test whether applying high-intensity pulsed electromagnetic fields to both the knee and quadriceps reduces pain and improves function more than applying it only to the knee in adults 60 and older with knee osteoarthritis.

  Recruiting Hospital Civil de Guadalajara · Guadalajara, Jalisco · NCT07198750

• Quadruple block plus adductor canal block for knee surgery pain

  This study tests whether adding a quadruple nerve block to the standard adductor canal block reduces pain after total knee replacement.

  Recruiting GCS Ramsay Santé pour l'Enseignement et la Recherche · Quincy-sous-Sénart and 1 other locations · NCT06920186

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.