Comparing different concentrations of sodium hypochlorite for treating irreversible pulpitis in teeth
Official title: Outcome Following Use of Different Concentrations of Sodium Hypochlorite as Wound Lavage and Hemostatic Agent in Partial Pulpotomy: A Randomised Control Trial
Run by Postgraduate Institute of Dental Sciences Rohtak · NCT06433245 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing whether using 3% or 5% sodium hypochlorite can help treat irreversible pulpitis in adult molars and improve patients' comfort and quality of life after the procedure.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 15 Years to 40 Years |
| Sex | All |
| Enrollment | 116 (estimated) |
| Sponsor | Postgraduate Institute of Dental Sciences Rohtak Academic / other |
| Locations | 1 site (Rohtak, Haryana) |
| Trial ID | NCT06433245 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients with mature permanent mandibular molars exhibiting clinical signs of irreversible pulpitis and normal periapical status.
✕Probably not a fit
Patients with non-restorable teeth, necrotic pulp, or other significant dental issues will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the effectiveness of 3% versus 5% sodium hypochlorite (NaOCl) as a wound lavage and hemostatic agent during partial pulpotomy in mature permanent mandibular molars diagnosed with irreversible pulpitis. Participants will undergo a randomized control trial where clinical and radiographic outcomes will be assessed at 12 months, alongside evaluations of oral health-related quality of life (OHRQoL) and pain experiences at various intervals post-treatment. The study seeks to clarify the impact of different NaOCl concentrations on treatment success and patient comfort.
Why it matters
Potential benefit: If successful, this study could enhance the effectiveness of partial pulpotomy treatments, leading to better patient outcomes and reduced pain.
How similar studies have gone: Previous studies have indicated the importance of sodium hypochlorite in vital pulp therapy, but this specific comparative analysis of concentrations is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Mature permanent mandibular molars. 2. Teeth with clinical diagnosis of symptomatic irreversible pulpitis 3. Patients having normal periapical status with periapical index (PAI) score ≤ 2 4. Periodontally healthy teeth 5. Patients having physical status of class 1 or 2 according to ASA classification 6. Pulpal bleeding can be controlled within 6 minutes. 7. Presence of extremely deep carious lesion on radiograph - Exclusion Criteria: 1) Non restorable teeth 2) Necrotic pulp evident upon exposure 3) Negative response to vitality test 4) Presence of sinus tract 5) Presence of soft tissue swelling 6) Radiographic signs of internal or external root resorption 7) Pregnant women -
Where it's running
-
Pigds
Rohtak, Haryana, India Recruiting
Study contacts
- Study coordinator: Dr. Pankaj Sangwan, MDS
- Email: drps_1@yahoo.co.in
- Phone: 9996112202
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Pulpal inflammation and full pulpotomy outcomes in deeply carious mandibular molars
This study tests whether levels of inflammatory markers IL-1β and IL-6 in deeply decayed mandibular molars predict the success of a full pulpotomy in adults with moderate to severe pulpitis.
-
Impact of a 1-file rotary system on debris extrusion during root canal treatment
This study tests whether using a single-file AF One system during root canal shaping reduces postoperative discomfort in teeth with irreversible pulpitis and mature roots.
-
Partial pulpotomy in mature lower molars with SIP using calcium hypochlorite vs sodium hypochlorite
This trial tests whether washing the exposed pulp with calcium hypochlorite or with sodium hypochlorite during partial pulpotomy in adults helps healing and reduces pain.
-
Direct pulp capping for deep and extremely deep caries in mature molars with reversible pulpitis
This study tests whether direct pulp capping works similarly for deep versus extremely deep caries in adult, mature mandibular molars with reversible pulpitis.
-
Direct pulp capping in lower molars with side (proximal) versus top (occlusal) cavities: does the cavity location matter?
This research will test whether direct pulp capping works as well for lower molars with side (proximal) cavities as for those with top (occlusal) cavities in people aged 15–40 who have reversible pulpitis.
-
Single Rotary File System vs Manual Instrumentation for Pulpectomy in Primary Molars
This trial tests whether using a single rotary file system for pulpectomy in primary molars changes how children behave during the procedure compared with traditional manual instruments.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.