Comparing different amoxicillin treatments for erythema migrans
Official title: Different Duration and Dosing of Amoxicillin in Patients With Erythema Migrans. A Randomized Clinical Trial.
Run by University Medical Centre Ljubljana · NCT03966014 · Data updated 2026-11-12
This study tests which length of amoxicillin treatment works best for people with erythema migrans, a common symptom of Lyme disease.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University Medical Centre Ljubljana Academic / other |
| Locations | 2 sites (Ljubljana and 1 other locations) |
| Status | Recruiting |
| Started | June 1, 2019 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | March 25, 2026 |
| Trial ID | NCT03966014 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with erythema migrans who meet the inclusion criteria.
✕Probably not a fit
Patients who are pregnant, have extracutaneous manifestations of Lyme borreliosis, or are immunocompromised may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of various amoxicillin treatment regimens in patients diagnosed with erythema migrans, a common manifestation of Lyme disease. Participants will be assigned to receive one of four treatment protocols: amoxicillin for 10 days, amoxicillin for 14 days, or a control group. The goal is to determine which regimen provides the best outcomes in terms of symptom resolution and overall efficacy. The study will involve close monitoring of patient responses to the different treatment durations.
Why it matters
Potential benefit: If successful, this study could lead to optimized treatment protocols for erythema migrans, improving patient outcomes and recovery times.
How similar studies have gone: While there have been studies on antibiotic treatments for Lyme disease, this specific comparison of amoxicillin regimens is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * erythema migrans Exclusion Criteria: * pregnancy * extracutaneous manifestations of Lyme borreliosis * immunocompromising state * serious adverse event to beta lactam antibiotic * receiving antibiotic with antiborrelial activity within 10 days
Where it's running
-
University Medical Centre Ljubljana
Ljubljana, Slovenia Recruiting -
University Medical Centre Ljubljana
Ljubljana, Slovenia Not yet recruiting
Study contacts
- Principal investigator: Daša Stupica, MD PhD — Department of Infectious Diseases, University Medical Centre Ljubljana, Slovenia
- Study coordinator: Daša Stupica, MD PhD
- Email: dasa.stupica@kclj.si
- Phone: +38631689324
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.