Comparing Dextromethorphan-Bupropion and SSRIs for Major Depression
Efficacy of Dextromethorphan-Bupropion Versus SSRIs in the Treatment of Major Depressive Disorder: A Randomized Controlled Trial
This study is testing if a new combination of dextromethorphan and bupropion can help adults with major depression feel better compared to standard antidepressants like SSRIs.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Combined Military Hospital Nowshera Government |
| Locations | 2 sites (Nowshera, KPK and 1 other locations) |
| Trial ID | NCT06957223 on ClinicalTrials.gov |
What this trial studies
This study compares the effectiveness of a combination of dextromethorphan and bupropion against standard selective serotonin reuptake inhibitors (SSRIs) in treating adults with major depressive disorder (MDD). Participants will be randomly assigned to receive either the dextromethorphan-bupropion combination or an SSRI like sertraline or escitalopram for a duration of 6 weeks. The primary goal is to measure the remission rate of depression using a validated scale, while secondary outcomes will assess changes in depressive symptoms and the safety of the treatments.
Who should consider this trial
Good fit: Ideal candidates are adults diagnosed with major depressive disorder who have moderate to severe symptoms.
Not a fit: Patients with a history of bipolar disorder, schizophrenia, or other psychotic disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new effective treatment option for patients suffering from major depressive disorder.
How similar studies have performed: While this approach is relatively novel, similar studies have shown promise in exploring alternative antidepressant combinations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Diagnosed with major depressive disorder (MDD) per DSM-5 criteria. Baseline depression score indicating moderate to severe depression Ability to provide informed consent Willing to comply with study requirements Exclusion Criteria: History of bipolar disorder, schizophrenia, or other psychotic disorders Current substance use disorder (within past 6 months) Active suicidal ideation requiring urgent intervention Pregnancy or breastfeeding Known hypersensitivity to study medications
Where this trial is running
Nowshera, KPK and 1 other locations
- Combined Military Hospital — Nowshera, Kpk, Pakistan (Not_yet_recruiting)
- Department of Psychiatry, Combined Military Hospital Nowshera — Nowshera, Kpk, Pakistan (Recruiting)
Study contacts
- Study coordinator: Asad Jan
- Email: asad2097@gmail.com
- Phone: 00923445515919
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.