Comparing dexmedetomidine alone versus with ketamine for ear and nose surgeries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares the efficacy and safety of dexmedetomidine alone versus a combination of dexmedetomidine and ketamine (ketodex) in achieving controlled hypotension during ear and nose surgeries. It assesses the analgesic and sedative effects of both drug regimens and evaluates their impact on recovery and hemodynamic stability. The trial focuses on patients aged 18-60 years who are scheduled for elective surgeries requiring controlled hypotensive anesthesia.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Age Range: Patients aged 18-60 years who are scheduled for elective Ear and nose surgeries requiring controlled hypotensive anesthesia.
* ASA Classification: Patients classified as American Society of Anesthesiologists (ASA) physical status I or II.
* Surgical Procedures: Individuals undergoing specific ear and nose surgeries where controlled hypotensive anesthesia is typically indicated.
* Stable Cardiovascular Health: Patients with stable cardiovascular function, without significant history of uncontrolled hypertension , hypotension or ischaemic heart diseases.

Exclusion Criteria

* Severe Cardiovascular Conditions: Patients with severe cardiovascular diseases such as congestive heart failure, uncontrolled hypertension , arrhythmias or ischaemic heart diseases .
* Any cardiac patients.
* Respiratory Conditions: Individuals with significant respiratory conditions like chronic obstructive pulmonary disease (COPD) or severe asthma.
* Drug Allergies: Patients with known hypersensitivity or allergic reactions to dexmedetomidine, ketamine or any other components of the study drugs.
* Pregnancy or Lactation: Pregnant or breastfeeding women, due to potential risks to the fetus or infant.
* Chronic Medication Use: Patients on chronic medications that could interfere with blood pressure regulation or interact with the study drugs (e.g., beta-blockers, MAO inhibitors).
* Patients with chronic liver or renal diseases.
* Psychiatric or Neurological Disorders: Individuals with severe psychiatric or neurological disorders that could impact the study outcomes or the patient's ability to consent.
* Substance Abuse: Patients with a history of substance abuse, particularly involving sedatives or opioids, which could affect anesthesia requirements or recovery.
* Coagulation Disorders: Individuals with coagulation disorders or on anticoagulant therapy, due to the increased risk of bleeding.

Where it's running

• Faculty of medicine
  Sohag, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.