Comparing Dexamethasone and Trypsin-Chymotrypsin for Reducing Pain After Wisdom Tooth Surgery
Official title: Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery
Run by B.P. Koirala Institute of Health Sciences · NCT06713733 · Data updated 2026-11-12
This study is testing whether an injection of dexamethasone or a pill of trypsin-chymotrypsin can help people feel less pain and swelling after having their wisdom teeth removed.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | B.P. Koirala Institute of Health Sciences Academic / other |
| Locations | 1 site (Dharān, Koshi) |
| Status | Recruiting |
| Started | September 25, 2024 |
| Main results expected | December 25, 2024 |
| Study ends | January 25, 2025 |
| Registry record updated | December 3, 2024 |
| Trial ID | NCT06713733 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are clinically healthy individuals requiring surgical removal of impacted mandibular third molars without any systemic diseases.
✕Probably not a fit
Patients with systemic diseases, allergies to the study drugs, or those currently on corticosteroids may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of submucosal dexamethasone versus oral trypsin-chymotrypsin in reducing postoperative complications such as pain, swelling, and trismus following the surgical removal of impacted lower third molars. The research focuses on the inflammatory response triggered by the surgery and aims to determine which treatment better alleviates these common sequelae. Patients will be monitored for their recovery and the severity of symptoms post-surgery to assess the clinical efficacy of each intervention.
Why it matters
Potential benefit: If successful, this study could lead to improved postoperative care and reduced discomfort for patients undergoing wisdom tooth extraction.
How similar studies have gone: Previous studies have shown that corticosteroids can effectively reduce postoperative inflammation, suggesting potential success for this comparative approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinically healthy patients (ASA I) patient free of any systemic diseases that could interfere with wound healing or surgical operation. * Free of any recent anti-inflammatory drug intake or being under long term treatment with medicaments that will obscure the assessment of the inflammatory response as NSAIDs, steroids, or antihistamines * Free from allergy to the drugs used in the study * Patients requiring surgical removal of the mandibular impacted third molar Exclusion Criteria: * Patients who are ASA II to ASA VI. * Patients already on corticosteroids through any route. * Patients with known allergy to any drugs. * Pregnant and lactating females * Patient not consenting to participate in the study
Where it's running
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Bp Koirala Institute of Health Sciences
Dharān, Koshi, Nepal Recruiting
Study contacts
- Study coordinator: sabin baniya, mds
- Email: sabinmds785@gmail.com
- Phone: +977-9841134900
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.