Comparing Dexamethasone and Magnesium for Pain Control in Kidney Surgery
The Efficacy of Dexamethasone Versus Magnesium Sulphate Added to Bupivacaine Used in Erector Spinae Plane Block for Perioperative Pain Control in Patients Undergoing Unilateral Nephrectomy
This study is testing whether adding dexamethasone or magnesium to a pain relief injection helps people having kidney surgery feel less pain and need less morphine afterward.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 78 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | National Cancer Institute, Egypt Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06501079 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of adding dexamethasone versus magnesium sulfate to bupivacaine in ultrasound-guided erector spinae plane blocks for patients undergoing unilateral nephrectomy. It is a randomized controlled trial involving three groups: one receiving bupivacaine alone, one with magnesium sulfate, and one with dexamethasone. The primary focus is on postoperative pain severity and morphine consumption. The study will be conducted at the National Cancer Institute, Cairo University, ensuring proper monitoring and patient safety throughout the procedure.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 who are scheduled for unilateral nephrectomy and classified as ASA II or III.
Not a fit: Patients who may not benefit include those with allergies to the medications used, those undergoing bilateral nephrectomy, or those with significant anatomical distortions.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing kidney surgery.
How similar studies have performed: Previous studies have shown promising results with similar approaches in pain management, but this specific comparison is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult (18 - 65) * Patients undergoing unilateral nephrectomy * ASA II / III Exclusion Criteria: * Patient refusal * Age less than 18 years * Allergy to any of the studied medications * Mid line incision * Bilateral nephrectomy * Distorted anatomy of the back (e.g. kyphoscoliosis) * Known neurologic disorders, psychiatric disorder or chronic pain * Local infection * Hemodynamic instability
Where this trial is running
Cairo
- National Cancer institute - Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Ahmed M Soliman
- Email: ams21787arif@hotmail.com
- Phone: 01286979695
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.