Comparing Dexamethasone and Lidocaine for Postoperative Sore Throat Relief in Shoulder Surgery

Topical Dexamethasone Versus Topical Lidocaine Spray to Reduce Post-intubation Sore Throat in Shoulder Arthroscopic Surgeries: A Comparative Study

Phase2; Phase3 Interventional Pharos University in Alexandria · NCT06266481

This study is testing whether a throat spray with dexamethasone or lidocaine can help reduce sore throat after shoulder surgery.

Quick facts

PhasePhase2; Phase3
Study typeInterventional
Enrollment100 (estimated)
Ages18 Years to 50 Years
SexAll
SponsorPharos University in Alexandria Academic / other
Locations1 site (Alexandria)
Trial IDNCT06266481 on ClinicalTrials.gov

What this trial studies

This study investigates the effectiveness of topical dexamethasone versus topical lidocaine spray in reducing postoperative sore throat (POST) in patients undergoing shoulder arthroscopic surgeries. A total of 100 patients will be randomized into two groups, with one group receiving an endotracheal tube soaked in dexamethasone and the other group receiving a lidocaine-sprayed tube. The severity of sore throat will be assessed following extubation to determine which intervention is more effective in managing this common complication of anesthesia. The study aims to provide insights into the prophylactic benefits of these treatments.

Who should consider this trial

Good fit: Ideal candidates for this study are patients aged 18 to 50 years, of ASA physical status I or II, undergoing shoulder arthroscopic surgeries.

Not a fit: Patients with anticipated difficult airways, allergies to steroids, or those with certain medical conditions such as diabetes or GERD may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could significantly reduce the incidence and severity of postoperative sore throat, improving patient comfort and recovery.

How similar studies have performed: Previous studies have shown promising results with both dexamethasone and lidocaine in managing postoperative sore throat, suggesting that this approach may be effective.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* •Patients belonging to ASA physical status I, II

  * Patients between age18 to 50 years
  * Patients belonging to both genders.
  * patients undergoing shoulder arthroscopic surgeries.
  * Patients with fasting blood glucose \<100 mg/dl or random blood sugar \<140 mg/dl.

Exclusion Criteria:

* Patients who are not willing to give consent for participation in the study

  * Patients with anticipated difficult airway
  * Patients who are allergic to steroids.
  * Patients with ASA physical status III, IV
  * Diabetic patients.
  * Patients on steroids
  * Patients requiring nasogastric tube or throat pack.
  * Patients posted for head and neck surgeries.
  * patient with GERD
  * Pregnant patients
  * preexisting upper respiratory tract infection.

Where this trial is running

Alexandria

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Postoperative Sore ThroatSore-throat postoperativedexamesthsone10% lidocaine
Last reviewed 2026-06-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.