Comparing demineralized dentin grafts and xenografts for dental implants in the esthetic zone
Official title: Clinical and Radiographic Evaluation of the Peri-implant Tissue Changes Around Early Placed Implants in the Esthetic Zone With Contour Augmentation Using Autogenous Partially Demineralized Dentin Graft Versus Xenograft: A RCT
Run by Cairo University · NCT06164353 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing whether using a special type of tooth graft or a different kind of graft helps people with a missing tooth grow better bone around dental implants in the front of their mouth.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Cairo University Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06164353 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy adults aged 20 and older with a single non-restorable tooth in the esthetic zone and a thin buccal plate of bone.
✕Probably not a fit
Patients with systemic diseases affecting bone healing, such as diabetes or Paget's disease, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of partially demineralized dentin grafts compared to xenografts in promoting bone regeneration around dental implants in the esthetic zone. It focuses on patients with a single non-restorable tooth and a thin buccal plate of bone, assessing the potential for contour augmentation. The methodology involves using a collagen membrane to cover the grafts and evaluating their osteoinductive properties. The study aims to determine which graft type yields better outcomes in terms of bone formation and implant stability.
Why it matters
Potential benefit: If successful, this study could improve dental implant outcomes and aesthetic results for patients requiring bone augmentation.
How similar studies have gone: Previous studies have shown promising results with demineralized dentin grafts, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adults aged ≥20 years. 2. Mild smokers \<1 pack of cigarettes a day 3. Capable of understanding or signing the informed consent form before surgery and capable of meeting oral cleaning requirements for implant placement 4. Healthy individuals with no systemic disease 5. Patients who have a single non-restorable tooth in the esthetic zone 6. Thin buccal plate of bone \< 1mm prior to tooth extraction indicated for early implant placement with the ability to place a bone level implant able to achieve 35 N cm stability after placement. Exclusion Criteria: * 1) A habit of bruxism or inability to achieve requirements for oral cleaning 2) The presence of acute or chronic infection at the site of tooth extraction with lack of treatment for periodontal disease, or x-rays showing loss of alveolar bone on the adjacent teeth 3) Subjects who have a systemic disease which affects bone healing as diabetes and Paget's disease 4) Use of steroid therapy or under current treatment by chemotherapy or radiation therapy to the head and neck (as Bisphosphonates) 5) Pregnant or breastfeeding women
Where it's running
-
Rana Saeed Al Qahtani
Cairo, Egypt Recruiting
Study contacts
- Principal investigator: rana Sa Al Qahtani, master — research ethics committee , cairo university
- Study coordinator: rana Sa Al Qahtani, master
- Email: rana.saeed@dentistry.cu.edu.eg
- Phone: +201069792005
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.