Comparing demineralized dentin grafts and xenografts for dental implants in the esthetic zone
Clinical and Radiographic Evaluation of the Peri-implant Tissue Changes Around Early Placed Implants in the Esthetic Zone With Contour Augmentation Using Autogenous Partially Demineralized Dentin Graft Versus Xenograft: A RCT
This study is testing whether using a special type of tooth graft or a different kind of graft helps people with a missing tooth grow better bone around dental implants in the front of their mouth.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 20 Years and up |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06164353 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of partially demineralized dentin grafts compared to xenografts in promoting bone regeneration around dental implants in the esthetic zone. It focuses on patients with a single non-restorable tooth and a thin buccal plate of bone, assessing the potential for contour augmentation. The methodology involves using a collagen membrane to cover the grafts and evaluating their osteoinductive properties. The study aims to determine which graft type yields better outcomes in terms of bone formation and implant stability.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 20 and older with a single non-restorable tooth in the esthetic zone and a thin buccal plate of bone.
Not a fit: Patients with systemic diseases affecting bone healing, such as diabetes or Paget's disease, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve dental implant outcomes and aesthetic results for patients requiring bone augmentation.
How similar studies have performed: Previous studies have shown promising results with demineralized dentin grafts, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adults aged ≥20 years. 2. Mild smokers \<1 pack of cigarettes a day 3. Capable of understanding or signing the informed consent form before surgery and capable of meeting oral cleaning requirements for implant placement 4. Healthy individuals with no systemic disease 5. Patients who have a single non-restorable tooth in the esthetic zone 6. Thin buccal plate of bone \< 1mm prior to tooth extraction indicated for early implant placement with the ability to place a bone level implant able to achieve 35 N cm stability after placement. Exclusion Criteria: * 1) A habit of bruxism or inability to achieve requirements for oral cleaning 2) The presence of acute or chronic infection at the site of tooth extraction with lack of treatment for periodontal disease, or x-rays showing loss of alveolar bone on the adjacent teeth 3) Subjects who have a systemic disease which affects bone healing as diabetes and Paget's disease 4) Use of steroid therapy or under current treatment by chemotherapy or radiation therapy to the head and neck (as Bisphosphonates) 5) Pregnant or breastfeeding women
Where this trial is running
Cairo
- Rana Saeed Al Qahtani — Cairo, Egypt (Recruiting)
Study contacts
- Principal investigator: rana Sa Al Qahtani, master — research ethics committee , cairo university
- Study coordinator: rana Sa Al Qahtani, master
- Email: rana.saeed@dentistry.cu.edu.eg
- Phone: +201069792005
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.