Comparing demineralized dentin graft and bone graft for treating periodontal defects

Clinical and Radiographic Evaluation of Autogenous Demineralized Dentin Graft Versus Autogenous Bone Graft in Management of Periodontal Intrabony Defects Using Modified Minimally Invasive Surgical Technique: A Non-Randomized Clinical Trial

This study is testing if using a special type of tooth material can work as well as traditional bone grafts to help heal gum problems in patients.

Quick facts

• Phase: PHASE4
• Study type: Interventional
• Enrollment: 24 (estimated)
• Ages: 18 Years to 50 Years
• Sex: All
• Sponsor: Cairo University (other)
• Locations: 1 site (Cairo)
• Trial ID: NCT06048042 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate the effectiveness of autogenous demineralized dentin as a bone graft substitute compared to traditional autogenous bone grafts in treating intrabony periodontal defects. Patients with specific periodontal conditions will undergo a modified minimally invasive surgical technique (M-MIST) after receiving initial oral hygiene instructions and debridement. The study will assess clinical attachment gain and bone fill through clinical and radiographic evaluations over a six-month follow-up period. The goal is to develop a less invasive and cost-effective treatment option for periodontal defects.

Who should consider this trial

Good fit: Ideal candidates are motivated adults aged 18 and older with specific types of intra-bony defects in their teeth.

Not a fit: Patients who are medically compromised, pregnant, uncooperative, smokers, or have systemic diseases affecting healing may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could provide a more effective and affordable treatment option for patients with periodontal intrabony defects.

How similar studies have performed: While the use of autogenous demineralized dentin has shown promise in socket preservation, this specific comparison with autogenous bone grafts is relatively novel.

Eligibility criteria

Inclusion Criteria:

* Patient-related criteria:

  * Motivated patient 18 years of age or order.
  * Patient consulting in the outpatient clinic.
  * Patient ready to perform oral hygiene instructions.
  * Provide informed consent.
  * Accepts the 6 months follow-up period.
* Teeth related criteria:

  * Tooth with two or three-walled intra-bony defect, probing depth ≥ 5mm with intra osseous defect ≥ 3mm.
  * Mature permanent tooth.
  * Unrestorable tooth or fractured tooth beyond restoration, impacted third molar or supernumerary tooth to be extracted and used as whole tooth graft inside the intrabony defect.

Exclusion Criteria:

* Patient-related criteria:

  * Medically compromised patients.
  * Pregnant women.
  * Uncooperative patients.
  * Smokers.
  * Systemic diseases that may compromise healing or bone metabolism (e.g diabetes, hyperthyroidism).
  * Failure to maintain good oral hygiene.
* Teeth related criteria:

  * Teeth with supra-bony defects.
  * Teeth with grade III mobility.
  * Teeth having interproximal craters, grade III furcation involvement, and grade III mobility.
  * Presence of caries or overhanging restorations.
  * Presence of peri-apical injuries.

Where this trial is running

Cairo

• Faculty of Dentistry, Cairo University — Cairo, Egypt (RECRUITING)

Study contacts

• Principal investigator: Ghada M. Abouhussein, Bachelor — Cairo University
• Study coordinator: Ghada M. Abouhussein, Bachelor

Conditions: Intrabony Periodontal Defect, Demineralized dentin graft, Autogenous bone graft, modified minimally invasive surgical technique, M-MIST