Comparing CT angiography and four‑vessel angiogram to confirm complete cerebral infarction (brain death)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study at Karolinska University Hospital compares a novel CT angiography protocol with conventional four‑vessel angiography as ancillary tests to determine complete cerebral infarction. Eligible adults have severe acute brain injury and require four‑vessel angiography under Swedish law, while patients on ECMO or deemed too unstable for CT are excluded. Imaging will be performed per clinical need and the CT protocol's diagnostic performance will be compared to the four‑vessel angiogram using measures such as concordance, sensitivity, and specificity. The goal is to determine whether the CT protocol can provide equivalent diagnostic information with fewer risks or logistical challenges.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults 18 years or older
* Ongoing critical care due to severe acute brain injury
* Four vessel angiography necessary for the determination of complete cerebral infarction, according to Swedish legislation

Exclusion Criteria:

* Treatment with extracorporeal membrane oxygenation (ECMO)
* Radiologic examination by computed tomography deemed too challenging due to respiratory or circulatory instability, as determined by responsible clinician

Where it's running

• Karolinska University Hospital
  Stockholm, Sweden Recruiting

Study contacts

• Study coordinator: Peter C Rudberg, M.D. Ph.D.
• Email: peter.rudberg@ki.se
• Phone: +46-8-1237000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Heart assessment to check repeat-stroke risk in people with atrial fibrillation

  This project will test whether detailed heart examinations can find which people with atrial fibrillation who just had an ischemic stroke are at high risk of having another stroke.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT06954610

• Evaluating therapy for patients with minor strokes and large vessel occlusion

  This study is testing different treatment options for patients with minor strokes caused by blocked large blood vessels to see which ones help them recover better.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang · NCT06633809

• Early rehabilitation using EEG neurofeedback for stroke recovery

  This study tests if using brainwave feedback along with regular rehab can help stroke patients recover better use of their arms.

  Recruiting Rennes University Hospital · Rennes · NCT05884762

• Tenecteplase or Reteplase Bridging Before Thrombectomy in Acute Ischemic Stroke

  This trial tests whether giving tenecteplase or reteplase before mechanical thrombectomy helps people with acute ischemic stroke due to large vessel occlusion, compared with doing thrombectomy alone.

  Recruiting Phase 3 Beijing Tiantan Hospital · Beijing, Beijing Municipality and 4 other locations · NCT07748039

• Minocycline after successful recanalization in acute anterior circulation stroke

  This trial tests whether adding minocycline after a successful endovascular thrombectomy helps people recover better after an acute anterior circulation stroke.

  Recruiting Phase 2/3 Tongji Hospital · Wuhan, Hubei · NCT07594314

• Using remote ischemic conditioning to improve outcomes in acute ischemic stroke patients undergoing thrombectomy

  This study tests if a new treatment called remote ischemic conditioning can help stroke patients recover better after a procedure to remove a blood clot.

  Recruiting at 60 sites Phase 3 Capital Medical University · Suzhou, Anhui and 69 other locations · NCT06559241

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.