Comparing CSF samples from different sites in external ventricular drains
Comparison of Different CSF Sampling Sites on External Ventricular Drains
This study is testing if cerebrospinal fluid taken from different parts of external ventricular drains can give the same useful information, which could make sampling safer for patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 55 (estimated) |
| Sex | All |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 1 site (Leuven) |
| Trial ID | NCT05254353 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the differences between cerebrospinal fluid (CSF) samples taken from proximal and distal sites of external ventricular drains (EVDs). By analyzing the characteristics of these samples, the study seeks to determine if distally sampled CSF can provide similar information as proximal samples, potentially reducing the need for more invasive sampling methods. The study involves patients with EVDs, who will have their CSF sampled and tested for various parameters such as protein levels, glucose levels, and white cell counts. The findings could lead to safer and more efficient practices in neurosurgery.
Who should consider this trial
Good fit: Ideal candidates include patients with an external ventricular drain in place, regardless of their underlying medical condition.
Not a fit: Patients who are scheduled for removal of their drain within 48 hours will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could minimize the risks associated with CSF sampling while maintaining effective monitoring for complications like ventriculitis.
How similar studies have performed: While this approach is being evaluated, similar studies have not been widely reported, making this a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with an EVD in place regardless of the underlying pathology. * Written informed consent to participate in the study must be obtained from the subject. If the subject is not capable of self-consent, all efforts will be made to locate a legally acceptable representative to act on behalf of the subject. When the patient is considered capable to consent but physically unable to sign an informed consent form and a representative is not available an impartial witness can attend the informed consent process. \- Males and females of all ages, including children and pregnant females Exclusion Criteria: * Patients in whom the removal of the drain is planned within 48 hours, before routine sampling, will be excluded.
Where this trial is running
Leuven
- UZ Leuven — Leuven, Belgium (Recruiting)
Study contacts
- Principal investigator: Philippe De Vloo, prof.dr. — UZ Leuven
- Study coordinator: Philippe De Vloo, prof.dr.
- Email: neurochirurgie@uzleuven.be
- Phone: 016 344290
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.