Comparing coronary flow and microvascular measures before and after intracoronary nitroglycerin in people with angina and non-blocking coronary arteries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-arm, multi-center prospective interventional study enrolling about 50 adults referred for coronary angiography for angina with non-obstructive coronary arteries (ANOCA/INOCA). Participants will undergo invasive coronary reactivity testing (CRT) with measurements of coronary flow reserve (CFR), index of microcirculatory resistance (IMR), transit time, Pa and Pd before any intracoronary nitrate. After an intracoronary nitroglycerin dose (200–500 mcg) the same CRT measurements will be repeated. The primary outcome is change in CFR before versus after nitroglycerin, with secondary outcomes including IMR, Pd, Pa, RRR, and transit times, analyzed using paired t-tests and generalized estimating equations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged 18 or older
2. Patient being evaluated for ANOCA or INOCA
3. Clinical suspicion for angina
4. Patient should be able to comply with the protocol.
5. Provide written informed consent before study participation.

Exclusion Criteria:

1. Existing coronary artery disease
2. Previous percutaneous interventions within the coronaries
3. Current use (within 48 hours) of long-acting nitrate therapies
4. Current use (within 48 hours) of PDE-5 inhibitors (sildenafil, tadalafil)
5. Any other condition or co-morbidity which, in the opinion of the investigator or operator, may pose a significant hazard to the subject if he or she is enrolled in the study.
6. Children below 18 years, prisoners, pregnant people and patients who are unable to provide consent are excluded.

Where it's running

• Baylor Scott & White The Heart Hospital - Plano
  Plano, Texas, United States Recruiting

Study contacts

• Study coordinator: Bonnie Ostergren
• Email: Bonnie.Ostergren@bswhealth.org
• Phone: 469-814-4181

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.