Comparing conventional endodontic treatment with photodynamic therapy for root canal disinfection
Effectiveness of Photodynamic Therapy Combined With Conventional Endodontic Treatment in the Disinfection of Root Canals in Patients With Apical Lesion: a Randomized Clinical Trial
NA · Universidad de La Frontera · NCT05916859
This study is testing if adding a special light treatment to regular root canal therapy can help people with tooth infections feel better and heal faster.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 159 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Universidad de La Frontera (other) |
| Drugs / interventions | radiation |
| Locations | 1 site (Santiago) |
| Trial ID | NCT05916859 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of conventional endodontic treatment versus endodontic treatment combined with photodynamic therapy (PDT) in patients with apical lesions. It will involve a randomized, controlled, and blinded design with three treatment groups: a placebo group receiving standard treatment, a group receiving standard treatment with PDT for 10 seconds, and another for 20 seconds. Clinical and radiographic examinations will assess the presence and size of apical lesions, while microbiological evaluations will measure root canal disinfection. The success rates of the treatments will be compared six months post-treatment.
Who should consider this trial
Good fit: Ideal candidates include adult patients with pulp necrosis and apical lesions who do not have any general biological risks.
Not a fit: Patients who are pregnant or require complex dental rehabilitation due to significant coronal destruction may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve the effectiveness of root canal treatments and enhance patient outcomes.
How similar studies have performed: While the use of photodynamic therapy in dental treatments is emerging, this specific combination with conventional endodontic treatment is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients eligible for this study must comply with the following for randomization: 1. Adult patients of either sex 2. No general biological risk 3. At least 1 molar with pulp necrosis and apical lesion Exclusion Criteria: 1. Pregnancy 2. Patients requiring complex dental rehabilitation due to major coronal destruction 3. Individuals with cognitive disability making conventional treatment impossible
Where this trial is running
Santiago
- Universidad San Sebastián — Santiago, Chile (RECRUITING)
Study contacts
- Principal investigator: Nilton Alves, PhD — Universidad de La Frontera
- Study coordinator: Nilton Alves, PhD
- Email: nilton.alves@ufrontera.cl
- Phone: 993966898
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Endodontic Treatment, Periapical Diseases, Photodynamic Therapy, apical lesion, endodontic treatment, infra-red laser