Comparing contraceptive implant discontinuation rates with and without additional support

Reduction of Premature Discontinuation of Contraceptive Implants by Advance Provision of an OCP-based Participant Intervention: Randomized Clinical Trial

Phase 4 Interventional University of Colorado, Denver · NCT04828824

This study is testing if young women aged 14 to 22.9 who get extra support, like advance contraceptive pills, are less likely to stop using their contraceptive implants compared to those who only receive standard counseling.

Quick facts

PhasePhase 4
Study typeInterventional
Enrollment600 (estimated)
Ages14 Years to 23 Years
SexFemale
SponsorUniversity of Colorado, Denver Academic / other
Locations1 site (Aurora, Colorado)
Trial IDNCT04828824 on ClinicalTrials.gov

What this trial studies

This study aims to compare the rates of discontinuation of etonogestrel contraceptive implants among young women aged 14 to 22.9 years who receive advance provision of combined oral contraceptive pills and a bleeding rescue regimen versus those who receive standard counseling. The primary objective is to assess whether the additional support leads to lower discontinuation rates. Secondary objectives include evaluating participant satisfaction and the need for clinical follow-up in the year following implant initiation.

Who should consider this trial

Good fit: Ideal candidates are young women aged 14 to 22.9 years who are initiating the etonogestrel implant for the first time.

Not a fit: Patients who have contraindications to estrogen-containing birth control or those planning to become pregnant within the next 12 months may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to improved retention rates of contraceptive implants and higher satisfaction among users.

How similar studies have performed: While there is limited data on this specific approach, similar studies have shown that additional support can improve contraceptive adherence and satisfaction.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. You are between ages of 14 to 22.9 years.
2. Started etonogestrel implant for the first time and have never used the implant before.

Exclusion Criteria:

1. There is any contraindication to estrogen containing birth control.
2. Desire of pregnancy in next 12 months.
3. Plans to move from the area in next 12 months and is not able to come to the clinic.

Where this trial is running

Aurora, Colorado

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Contraception Behavior
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.