Comparing collagen matrix and membrane for wound protection during ridge preservation
A Randomized Controlled Trial Comparing Collagen Matrix to Collagen Membrane As Socket Seal in Alveolar Ridge Preservation
NA · University Hospital, Ghent · NCT06029322
This study is testing whether a collagen matrix or a collagen membrane works better to protect wounds after tooth extractions and help them heal properly.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 18 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | University Hospital, Ghent (other) |
| Locations | 1 site (Ghent, East Flanders) |
| Trial ID | NCT06029322 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to compare the effectiveness of a collagen matrix versus a collagen membrane in protecting wounds during alveolar ridge preservation (ARP) after tooth extraction. Eighteen patients will participate, each undergoing two surgical sites where one will receive the collagen matrix and the other the collagen membrane, determined by a coin flip. The study will assess soft tissue thickness and other healing parameters using low-dose CBCT imaging at various intervals post-surgery. The primary outcome is the difference in soft tissue thickness at four months, while secondary outcomes include wound healing scores and changes in bone and soft tissue dimensions.
Who should consider this trial
Good fit: Ideal candidates are adults over 21 with good oral hygiene who require alveolar ridge preservation after the extraction of two teeth.
Not a fit: Patients with systemic diseases, pregnancy, untreated periodontitis, or active infections around the failing tooth may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve wound healing outcomes for patients undergoing alveolar ridge preservation.
How similar studies have performed: Previous studies have shown promising results in using collagen-based materials for wound healing, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least 21 years old * Good oral hygiene defined as a full-mouth plaque score ≤ 25% (O'Leary, Drake, \& Naylor, 1972) * Need for ARP after tooth extraction at two sites in the maxilla or mandible with \> 50% buccal bone present following tooth extraction * Signed informed consent Exclusion Criteria: * Any systemic disease * Pregnancy * Smoking (will be specifically asked) * Untreated periodontitis * Untreated caries lesions * Suppuration and/or active infection around the failing tooth * Midfacial recession at the failing tooth
Where this trial is running
Ghent, East Flanders
- Ghent University Hospital — Ghent, East Flanders, Belgium (RECRUITING)
Study contacts
- Study coordinator: Véronique Christiaens, PhD
- Email: vchristi.Christiaens@UGent.be
- Phone: +3293324017
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Oral Soft Tissue Conditions, collagen matrix, collagen membrane, alveolar ridge preservation, CBCT analysis, Volumetric analysis, peri-implant health, oral implant