Comparing collagen and PRF membranes for bone augmentation in dental procedures
Evaluation of Collagen Versus Platelet Rich Fibrin Membrane on the Osteogenic Potential of Bone Marrow Aspirate Concentrate (BMAC) for Lateral Sinus Floor Augmentation : A Randomized Clinical Trial.
This study is testing whether collagen membranes or platelet-rich fibrin (PRF) membranes help improve bone healing better during sinus lift procedures for patients with a certain amount of bone loss in their upper jaw.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 2 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Cairo) |
| Trial ID | NCT05985317 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of collagen membranes versus platelet-rich fibrin (PRF) membranes placed over a mixture of bone marrow aspirate concentrate and bovine graft during sinus lift procedures. The goal is to determine which membrane type enhances the osteogenic potential of the graft, thereby improving bone healing and integration before dental implant placement. Patients with a minimum of 4 mm vertical bone height deficiency in the posterior maxilla will be included, and their healing outcomes will be monitored post-procedure.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with a significant bone height deficiency in the posterior maxilla requiring augmentation.
Not a fit: Patients with systemic diseases, sinus pathosis, or conditions affecting bone quality may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve bone healing and integration for patients undergoing dental implant procedures.
How similar studies have performed: Previous studies have shown promising results with similar membrane approaches in bone augmentation, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who has as deficient as 4 mm vertical bone height in posterior maxilla that need bone augmentation before delayed implant placement. * Highly motivated patients * Age more than 18 years Exclusion Criteria: * Patients suffering from any systemic disease or those under any medication that may interfere with normal bone healing. * Patients suffering from any sinus pathosis. * Patients with conditions that could potentially compromise Bone Marrow ( BM)quality, including history of hematologic malignancy, current chemotherapy, BM suppressive and anti-platelet medications, previous BM Aspiration, or acute illness. * Heavy smoker (\> 20 cigarettes daily)
Where this trial is running
Cairo
- Faculty of Dentistry, Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Walaa Kadry
- Email: walaakadry@dentistry.cu.edu.eg
- Phone: +201061527359
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.