Comparing CO2 and Thulium Lasers for Hyaluronic Acid Delivery in Aging Skin

In Vivo Visualisation of Hyaluronic Acid After CO2 Laser Compared to Thulium Laser Treatment

Not applicable Interventional Universitätsklinikum Hamburg-Eppendorf · NCT06431282

This study is testing whether using CO2 or thulium lasers to deliver hyaluronic acid can improve skin quality for healthy adults without the need for injections.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment30 (estimated)
Ages18 Years and up
SexAll
SponsorUniversitätsklinikum Hamburg-Eppendorf Academic / other
Locations1 site (Hamburg)
Trial IDNCT06431282 on ClinicalTrials.gov

What this trial studies

This study investigates the effectiveness of delivering hyaluronic acid (HA) into the skin using two different laser treatments: CO2 laser and thulium laser. The goal is to assess the morphological cellular changes in the skin after HA delivery following these laser treatments, which may offer a less invasive alternative to traditional injection methods. By comparing the outcomes of both laser approaches, the study aims to determine which method provides better skin quality improvement with fewer side effects. Healthy male and female participants will be recruited for this interventional study.

Who should consider this trial

Good fit: Ideal candidates for this study are healthy male and female patients seeking treatment for aging skin.

Not a fit: Patients who are pregnant, breastfeeding, or have open wounds in the treatment area will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a more effective and less invasive method for improving skin quality in aging patients.

How similar studies have performed: While there have been studies on laser treatments for skin rejuvenation, this specific comparison of CO2 and thulium lasers for HA delivery is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

\- healthy male and female patients

Exclusion Criteria:

* pregnancy, breast feeding
* open wounds at the area to be treated

Where this trial is running

Hamburg

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Aging Skin
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.