Comparing clonidine and granisetron to prevent shivering after spinal anesthesia
Intravenous Clonidine Versus Granisetron for Prevention of Post Spinal Anesthesia Shivering in Cesarean Section
This study is testing whether clonidine or granisetron can help prevent shivering in women having elective cesarean sections after receiving spinal anesthesia.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 186 (estimated) |
| Ages | 21 Years to 40 Years |
| Sex | Female |
| Sponsor | Zagazig University Government |
| Locations | 1 site (Zagazig) |
| Trial ID | NCT06031090 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of clonidine versus granisetron in preventing post spinal anesthesia shivering during elective cesarean sections. Shivering is a common complication that can cause discomfort and increase metabolic demands in patients. The study will involve administering either clonidine or granisetron, along with a control of normal saline, to assess which intervention is more effective in reducing shivering. The participants will be monitored for shivering episodes and related outcomes following spinal anesthesia.
Who should consider this trial
Good fit: Ideal candidates are healthy women aged 21-40 with a BMI of 18-30, scheduled for elective cesarean sections under spinal anesthesia.
Not a fit: Patients with chronic pain, significant comorbidities, or those who are uncooperative may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved comfort and reduced complications for patients undergoing cesarean sections.
How similar studies have performed: Previous studies have explored various medications for shivering prevention, but this specific comparison of clonidine and granisetron is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patient acceptance.,Aged between 21-40 years old, BMI: 18- 30 kg/m2, ASA: I and II., Scheduled for elective cesarean section under spinal anesthesia. - Exclusion Criteria: History of hypersensitivity to drugs used in this study,Patients with history of chronic pain and taking analgesics, Patients with sepsis and Significant cardiac, liver or renal diseases, Uncooperative patients or with psychiatric disorders that prevent surgery under spinal anesthesia, Atrio-ventricular block in any degree, cardiac arrhythmias, valvular heart disease, kidney or liver diseases, neuromuscular disorders and diabetes mellitus -
Where this trial is running
Zagazig
- Heba M Fathi — Zagazig, Egypt (Recruiting)
Study contacts
- Study coordinator: Heba M Fathi, M.D
- Email: heba_elgendi@yahoo.com
- Phone: 00201000143938
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.