Comparing ciprofol and propofol for anesthesia in heart surgery
Ciprofol Versus Propofol for Anesthesia Induction in Cardiac Surgery: A Randomized Double-blind Controlled Clinical Trial
This study is testing a new anesthesia called ciprofol to see if it works better and is safer than the usual anesthesia, propofol, for older patients having heart surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 55 Years to 75 Years |
| Sex | All |
| Sponsor | Shanghai East Hospital of Tongji University Academic / other |
| Locations | 1 site (Shanghai, Shanghai) |
| Trial ID | NCT06312345 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of ciprofol, a new intravenous anesthetic, compared to propofol for inducing anesthesia in patients undergoing cardiac surgery. The study focuses on patients aged 55 to 75 with specific cardiac function classifications and utilizes a randomized double-blind controlled design to ensure unbiased results. The trial aims to assess the safety and efficacy of ciprofol, particularly its rapid onset and reduced cardiovascular impact, in a surgical setting. By comparing these two anesthetics, the study seeks to provide insights into optimal anesthesia practices for cardiac procedures.
Who should consider this trial
Good fit: Ideal candidates for this study are elective surgery patients aged 55 to 75 with New York Heart Association class II or III cardiac functions.
Not a fit: Patients with a history of benzodiazepine allergy, significant liver or kidney insufficiency, or other specified exclusions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved anesthesia induction methods that enhance patient safety and comfort during cardiac surgeries.
How similar studies have performed: While ciprofol is a novel anesthetic, similar studies comparing anesthetic agents have shown promising results, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Elective surgery patients 2. Aged 55 to 75 3. New York Heart Association class II or III cardiac functions 4. Median sternotomy approach for coronary artery bypass grafting or heart valve replacement procedures Exclusion Criteria: 1. With a history of benzodiazepine allergy 2. Significant liver or kidney insufficiency 3. Coagulation dysfunction 4. Neurological or psychiatric disorders 5. Undergone major surgery within the past three months.
Where this trial is running
Shanghai, Shanghai
- Shanghai East Hospital of Tongji University — Shanghai, Shanghai, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.