Comparing cilostazol and aspirin for preventing stroke in patients with cerebral microbleeds

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the efficacy and safety of cilostazol compared to aspirin for the secondary prevention of stroke in patients who have experienced an acute non-cardioembolic ischemic stroke and have concurrent cerebral microbleeds. Participants will be randomly assigned to receive either cilostazol or aspirin, with their health monitored through baseline and follow-up assessments at various intervals over four years. The primary focus will be on stroke recurrence, while secondary endpoints will include other vascular events and safety assessments related to bleeding. The study seeks to determine if cilostazol is non-inferior to aspirin in this specific patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Acute ischemic stroke (within 1 month of onset)
* Non-cardioembolic stroke
* Presence of cerebral microbleeds (CMBs) confirmed by susceptibility-weighted imaging (SWI)

Exclusion Criteria:

* Previous diagnosis of cerebral amyloid angiopathy (CAA) according to the Boston 2.0 diagnostic criteria
* History of intracerebral hemorrhage highly suspected to be caused by CAA-related lobar hemorrhage
* Severe adverse reactions (such as active bleeding, severe allergies, etc.) to aspirin or cilostazol in the past, leading to non-compliance with medication
* Requirement for combined anticoagulant therapy
* Requirement for long-term dual antiplatelet therapy (\>1 month)

Where it's running

• Zhejiang Provincial People's Hospital
  Hangzhou, Zhejiang, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.