Comparing carvedilol and endoscopic band ligation for preventing esophageal variceal bleeding

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of carvedilol compared to endoscopic band ligation in preventing esophageal variceal bleeding in cirrhotic patients who also have arterial hypertension. It is a randomized controlled trial that aims to determine which intervention is more effective for primary prophylaxis in this high-risk population. The study includes patients over 18 years old with medium to large-sized esophageal varices and excludes those with a history of variceal bleeding or other significant health issues.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* • Aged \>18 years

  * Cirrhotic patients with arterial hypertension
  * Endoscopic evidence of medium/large-sized esophageal varices

Exclusion Criteria:

* • History of variceal bleeding or previous primary prevention of varices.

  * Portal vein thrombosis or previous porto-systemic shunts as TIPS.
  * Patients on drugs affecting portal pressure (beta blockers, nitrates).
  * Advanced cardiovascular disease including acute myocardial infarction, atrio-ventricular block, congestive heart failure, chronic peripheral ischemia, severe bradycardia.
  * Patients with severe respiratory diseases (COPD, bronchial asthma).
  * Uncontrolled diabetes mellitus
  * Renal impairment
  * Hepatocellular carcinoma
  * Allergy to carvedilol
  * Pregnancy or lactation

Where it's running

• Sherief Abd-Elsalam
  Tanta, Egypt Recruiting

Study contacts

• Principal investigator: Nabila Abd El-Nasser Abd El-Wahed El-Gazzar, ass. lect — Tanta University Faculty of medicine
• Study coordinator: Sherief Abd-Elsalam, ass. prof.
• Email: sheriefabdelsalam@yahoo.com
• Phone: 00201147773440

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.