Comparing CAD/CAM-milled and 3D-printed full-arch dental restorations

Performance of CAD/CAM Milled and 3D-printed Full-arch Implant-supported Provisionals Restorations: A Randomized Controlled Clinical Trial

Not applicable Interventional Universidad Complutense de Madrid · NCT05958043

This study is testing whether dental restorations made by milling or 3D printing work better for patients without teeth over a three-month period.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment20 (estimated)
Ages18 Years and up
SexAll
SponsorUniversidad Complutense de Madrid Academic / other
Locations1 site (Madrid)
Trial IDNCT05958043 on ClinicalTrials.gov

What this trial studies

This clinical trial compares the performance of CAD/CAM-milled and 3D-printed full-arch implant-supported provisional restorations in edentulous patients. Participants will receive either milled or printed provisional restorations and will be monitored for three months to assess mechanical behavior and optical properties. The study aims to determine if there are significant differences between the two fabrication methods in terms of their effectiveness and durability. The research is conducted at the Advanced Implant Prosthetics Clinic of the Complutense University of Madrid.

Who should consider this trial

Good fit: Ideal candidates are healthy adults over 18 years old who are edentulous and require a full-arch implant-supported fixed prosthesis.

Not a fit: Patients with contraindications for oral surgical procedures or those with severe bruxing habits may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved dental restoration options for edentulous patients, enhancing both functionality and aesthetics.

How similar studies have performed: While the use of CAD/CAM technology in dental restorations is established, the specific comparison of 3D printing versus milling for full-arch provisional restorations is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Males and females at least 18 years of age.
* Healthy patients; ASA I or ASA II.
* Maxillary, mandibular, or both maxillary edentulous patients whose prosthetic treatment plan is a full-arch implant-supported fixed prosthesis.
* Patients must have voluntarily signed informed consent, be willing and able to attend scheduled follow-up visits, and agree to have coded data collected and analyzed.

Exclusion Criteria:

* Any contraindications for oral surgical procedures.
* Smokers classified as "heavy smokers" above 10 cigarettes per day (or more than 1 cigar per day) or smokers of chewing tobacco.
* Subjects with drug or alcohol abuse.
* Severe bruxing habits.
* Conditions or circumstances that, in the opinion of the investigator, would preclude completion of participation in the study or interfere with the analysis of the study results.

Where this trial is running

Madrid

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Edentulous JawDental Prosthesis ComplicationDental Prosthesis FailureCAD/CAM3D-PrintedFull-arch provisional
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.