Comparing CABG and PCI for severe coronary artery disease and heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The STICH 3.0 study aims to determine if coronary artery bypass grafting (CABG) is more effective than percutaneous coronary intervention (PCI) in reducing all-cause mortality over five years in patients with severe coronary artery disease and impaired left ventricular systolic function. This study will pool and analyze individual patient data from various national randomized controlled trials to provide a comprehensive comparison of these two treatment methods. The primary focus is on long-term outcomes, particularly mortality rates, to address existing inconsistencies in observational studies regarding these interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>18 years
* LVEF ≤40%
* Extensive coronary artery disease (typically defined as a British Cardiovascular Intervention Society jeopardy score of ≥6, on a scale from 0 to 12, with higher scores indicating greater extent of disease).

Exclusion Criteria:

* Decompensated heart failure requiring inotropic/adrenergic support, invasive or non-invasive ventilation or intra-aortic balloon pump/ ventricular assist device therapy less than 48 hours prior to randomization;
* Valvular heart disease or any other cardiac conditions (e.g. LV aneurysm) indicating the need for surgical repair/replacement;
* Prohibitive bleeding risk or clinical scenario mandating avoidance of long-term dual antiplatelet therapy;
* Pregnancy;
* Circumstances likely to lead to poor treatment adherence;
* STEMI within 72 hours;
* PCI within 3 months.

Where it's running

• Dep of Cardiology, Sahlgrenska University Hospital
  Gothenburg, Sweden Recruiting

Study contacts

• Study coordinator: Björn Redfors, MD, PhD
• Email: bjorn.redfors@wlab.gu.se
• Phone: +46 313421000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.