Comparing breath test results in primary and secondary care settings
HOspital Versus Primary Care Breath Test Environment (HOPE) Study
This study is testing if breath test results are different when done in a regular doctor's office compared to a hospital to see if it can help identify patients who might need more tests.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Imperial College London Academic / other |
| Locations | 2 sites (London and 1 other locations) |
| Trial ID | NCT06611293 on ClinicalTrials.gov |
What this trial studies
The HOPE study aims to evaluate whether the volatile organic compound (VOC) profiles in exhaled breath differ between primary and secondary care environments. By assessing intra-subject variability, the study seeks to determine the reproducibility of breath test results regardless of the care setting. This non-invasive breath test could serve as an early triage tool for identifying high-risk patients, allowing for timely referrals for further investigations. Participants will provide breath samples that will be analyzed in a regional laboratory, with results guiding clinical decisions based on NICE guidelines.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are willing to provide informed consent.
Not a fit: Pregnant women will not benefit from this study as they are excluded from participation.
Why it matters
Potential benefit: If successful, this study could enhance early detection of diseases, leading to timely interventions and improved patient outcomes.
How similar studies have performed: Previous studies, such as the MAGIC study, have shown that breath testing is feasible in primary care, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Participants will be: * Aged ≥ 18 years old * Willing and able to provide informed consent to take part in study. Exclusion Criteria: * Pregnant women will be excluded from this study. With the exception of pregnant women, there are no additional strict exclusion criteria as individuals will act as their own control.
Where this trial is running
London and 1 other locations
- Imperial College London — London, United Kingdom (Not_yet_recruiting)
- Imperial College London — London, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Michael Fadel, BSc MBBS MRCS
- Email: m.fadel@imperial.ac.uk
- Phone: +44 (0)20 7594 3396
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.