Comparing Botox injections to combined medication for overactive bladder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of botulinum toxin type A bladder injections compared to a combination of Mirabegron and Solifenacin in patients with detrusor overactivity who have not responded to single-drug treatments. Participants will be divided into two groups, receiving either the Botox injection or the combined pharmacotherapy. The study will assess both subjective symptoms related to incontinence and objective measures such as urinary urgency and bladder capacity. Evaluations will be conducted using standardized questionnaires and urodynamic assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with detrusor overactivity which defined as a urodynamic observation characterized by involuntary detrusor contractions during the filling phase. Those who were refractory to monotherapy with either anti-muscarinics or β3-adrenoceptor agonists were enrolled for prospective study

Exclusion Criteria:

* Postvoid urine retention before treatment

Where it's running

• Mackay Memorial Hospital
  Taipei, Taiwan Recruiting

Study contacts

• Principal investigator: Hui-Hsuan Lau, MD — Mackay Memorial Hospital
• Study coordinator: Hui-Hsuan Lau, MD
• Email: huihsuan1220@gmail.com
• Phone: +886-2-25433535

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Comparing solifenacin or mirabegron with local estrogen to combined pharmacotherapy for overactive bladder

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• Comparing two treatments for women with overactive bladder

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• Educational video before urodynamic testing to see if it lowers anxiety

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• Perineal versus intravaginal electrical stimulation for idiopathic overactive bladder in women

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• Salbutamol effects on endurance athletes and screening for breathing limits

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  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07037511

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.