Comparing bone marrow in patients with follicular lymphoma and healthy controls
Bone Marrow and Follicular Lymphoma
This study looks at the differences in bone marrow cells between people with follicular lymphoma and healthy individuals to better understand what might cause relapses in the disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Rennes University Hospital Academic / other |
| Locations | 1 site (Rennes) |
| Trial ID | NCT06608147 on ClinicalTrials.gov |
What this trial studies
This prospective single-center study aims to investigate the differences in cell composition between the bone marrow of patients diagnosed with follicular lymphoma and that of healthy control subjects. By utilizing samples obtained during surgeries involving sternotomies, the study will establish a bone marrow bank for patients without hematological diseases, which will serve as a control cohort for future clinical trials. The research seeks to enhance understanding of the microenvironment in the bone marrow that may contribute to the relapses seen in follicular lymphoma patients.
Who should consider this trial
Good fit: Ideal candidates for this study are adults undergoing surgery involving a sternotomy who do not have a history of hematological malignancies.
Not a fit: Patients with a history of hematological malignancies or those currently receiving immunomodulating treatments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the mechanisms of follicular lymphoma relapses, potentially leading to improved treatment strategies.
How similar studies have performed: While the specific approach of this study is novel, similar studies have shown the importance of understanding the bone marrow microenvironment in hematological conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Major patient * Patient hospitalized in the thoracic, cardiac and vascular surgery department for surgery involving a sternotomy * Patient with free, informed, written consent * Patient covered by a health insurance scheme Exclusion Criteria: * History of haematological malignancy or haemogram disturbance * Immunomodulating treatment: immunosuppressants, corticoids, antineoplastics * Persons covered by articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the French Public Health Code (e.g. minors, protected adults, etc.)\].
Where this trial is running
Rennes
- CHU Rennes — Rennes, France (Recruiting)
Study contacts
- Study coordinator: Juliette Ferrant, MD
- Email: juliette.ferrant@chu-rennes.fr
- Phone: 0299282555
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.