Comparing blood-thinning therapies for patients with severe intracranial artery narrowing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study, known as CAPTIVA-MRI, is designed to analyze MRI biomarkers in patients with severe intracranial atherosclerotic stenosis (ICAS) who have experienced a stroke. It is an ancillary study to the CAPTIVA trial, which involves randomizing patients to different blood-thinning medications. The primary aim is to identify patients who do not respond to the best medical management through advanced MRI imaging techniques. The findings are expected to inform future ICAS trials and improve patient management strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Enrollment in the CAPTIVA trial: nondisabling symptomatic ischemic infarct stroke within 30 days secondary to 70-99% stenosis of the intracranial ICA, MCA, BA or VA
* Ability to obtain baseline study MRI within 14 days of CAPTIVA enrollmen

Exclusion Criteria:

* Unable or unwilling to undergo MRI, including pacemaker or other MRI contraindications per American College of Radiology guidelines62
* Gadolinium contrast allergy or acute or chronic kidney disease with eGFR\<30 ml/min/1.73m2

Where it's running

• University of Alabama Hospital
  Birmingham, Alabama, United States Recruiting
• Yale New Haven Hospital
  New Haven, Connecticut, United States Recruiting
• MedStar Washington Hospital Center
  Washington D.C., District of Columbia, United States Recruiting
• Baptist Medical Center Jacksonville
  Jacksonville, Florida, United States Recruiting
• Jackson Memorial Hospital, Miami
  Miami, Florida, United States Recruiting
• University of Illinois Hospital
  Chicago, Illinois, United States Recruiting

Study contacts

• Principal investigator: David Liebeskind, MD — University of California, Los Angeles
• Study coordinator: Ka-Ho Wong
• Email: ka-ho.wong@hsc.utah.edu
• Phone: 801-585-7575

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.