Comparing blood loss in vaginal hysterectomy with and without tranexamic acid
Official title: Do Patients Who Are Treated With Tranexamic Acid Loose Les Blood, Comparing to Patients Who Are Not Treated, During Vaginal Hysterectomy? a Randomized Control Study
Run by Wolfson Medical Center · NCT05921071 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if giving women tranexamic acid before a vaginal hysterectomy can help reduce blood loss during the surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | Women only |
| Enrollment | 80 (estimated) |
| Sponsor | Wolfson Medical Center Government |
| Locations | 1 site (H̱olon) |
| Trial ID | NCT05921071 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women in good health who are scheduled for elective vaginal hysterectomy due to pelvic organ prolapse.
✕Probably not a fit
Patients with a history of hypercoagulability disorders, renal impairment, or those receiving antithrombotic therapy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized control, double-blind study evaluates the effect of tranexamic acid on blood loss during elective vaginal hysterectomy. Women scheduled for the procedure will be randomly assigned to receive either 1 gram of tranexamic acid or a placebo (normal saline) intravenously before surgery. The study aims to determine if tranexamic acid can significantly reduce blood loss compared to the control group. A nurse will prepare the solutions based on randomization, ensuring the anesthesiologist is unaware of the treatment assignment.
Why it matters
Potential benefit: If successful, this study could lead to reduced blood loss during vaginal hysterectomy, improving patient outcomes and recovery times.
How similar studies have gone: Previous studies have shown that tranexamic acid can effectively reduce blood loss in various surgical procedures, suggesting potential success in this context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \*Women in general good health (defined as American Society of Anesthesiologists grade 1-2) who are about to undergo elective vaginal hysterectomy indicated by pelvic organ prolapse (POP). Exclusion Criteria: * allergy to TXA * familial or personal history of hypercoagulability disorder or thromboembolic events * impaired renal function or hematuria * patients receiving antithrombotic therapy * additional concurrent abdominal/ laparoscopic procedures * malignancy * Post-assignment exclusion will be executed in cases of conversion to laparotomy/ laparoscopy.
Where it's running
-
Wolfson medical center
H̱olon, Israel Recruiting
Study contacts
- Principal investigator: Ohad Gluck — Wolfson Medical Center
- Study coordinator: Ohad Gluck
- Email: ohadgluck@gmail.com
- Phone: 0528702255
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Comparing two types of hysterectomy procedures
This study is testing whether a new type of vaginal hysterectomy can help women recover faster and have fewer complications compared to the traditional method.
-
Comparing two methods for performing hysterectomy
This study is testing whether a new way of doing hysterectomy through the vagina is safer and easier for women with larger uteri compared to the traditional laparoscopic method.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.