Comparing blood-flow restricted exercise to traditional exercise for COPD patients
The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR):4 Randomized Crossover Studies
This study tests if exercising with blood-flow restriction can help people with COPD improve their strength and breathing better than traditional exercise.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | University of Zurich Academic / other |
| Locations | 1 site (Zurich) |
| Trial ID | NCT05163600 on ClinicalTrials.gov |
What this trial studies
This study investigates the acute cardiorespiratory responses to blood-flow restricted (BFR) exercise compared to traditional exercise regimens in both healthy individuals and those with Chronic Obstructive Pulmonary Disease (COPD). Participants will engage in strength training using a Leg Press machine, with specific methodologies designed to enhance muscle strength. The study employs a randomized crossover design to assess differences in exercise responses and blood pressure levels between the two training approaches. The goal is to determine if BFR training offers distinct advantages for individuals with COPD.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older diagnosed with COPD according to GOLD guidelines.
Not a fit: Patients with acute exacerbations of COPD or those with physical impairments that prevent participation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into more effective exercise regimens for improving the health and quality of life for COPD patients.
How similar studies have performed: Previous studies have shown promising results with blood-flow restricted training, suggesting potential benefits for muscle strength and cardiovascular responses.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion and exclusion for the healthy participants are defined by the following criteria. Inclusion criteria: * Age ≥ 18 years * Clinically healthy Exclusion criteria: * Physical or intellectual impairment precluding informed consent or protocol adherence * Non-German speaking (precluding informed consent) * Pain during exercise of any origin * Pregnancy * History of thromboembolic event in the lower extremity * Resting systolic blood pressure \<100 mmHg Inclusion and exclusion for the COPD participants are defined by the following criteria. Inclusion criteria: * Age ≥ 18 years * Diagnosed COPD according to GOLD-guidelines12 Exclusion criteria: * Physical or intellectual impairment precluding informed consent or protocol adherence * Non-German speaking (precluding informed consent) * Acute or recent (within the last 6 weeks) exacerbation of COPD * Pain during exercise of any origin * Pregnancy * History of thromboembolic event in the lower extremity * Resting systolic blood pressure \<100 mmHg
Where this trial is running
Zurich
- University Hospital Zürich — Zurich, Switzerland (Recruiting)
Study contacts
- Principal investigator: Christian Clarenbach, Dr. med — University of Zurich
- Study coordinator: Christan Clarenbach, Dr. med
- Email: Christian.clarenbach@usz.ch
- Phone: 044 255 22 21
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.