Comparing Biphasic Cuirass Ventilation to Non-invasive Positive Pressure Ventilation for Respiratory Failure
Impact of Negative Pressure Ventilation in Patients Hospitalized with Acute Hypercapnic Respiratory Failure
This study is testing if a new breathing support method called Biphasic Cuirass Ventilation works better than the usual Non-invasive Positive Pressure Ventilation for patients in the hospital with severe breathing problems.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 21 Years to 90 Years |
| Sex | All |
| Sponsor | University of Missouri-Columbia Academic / other |
| Locations | 1 site (Columbia, Missouri) |
| Trial ID | NCT06108284 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of Biphasic Cuirass Ventilation compared to standard Non-invasive Positive Pressure Ventilation in patients hospitalized with acute hypercapnic respiratory failure. Patients will be randomized into two groups: one receiving the intervention and the other receiving standard care. Clinical assessments and periodic blood gas sampling will be conducted to monitor patient progress and carbon dioxide levels. The study aims to determine if the new ventilation method can improve patient outcomes in this critical condition.
Who should consider this trial
Good fit: Ideal candidates are hospitalized patients diagnosed with acute hypercapnic respiratory failure and specific blood gas parameters.
Not a fit: Patients under 21, pregnant individuals, or those with contraindications for the cuirass ventilator will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more effective ventilation option for patients suffering from acute hypercapnic respiratory failure.
How similar studies have performed: While this approach is being tested in this pilot study, similar studies have shown varying degrees of success with non-invasive ventilation methods.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * admission diagnosis of hypercapnic respiratory failure * pH between 7.20-7.35 in an ABG sample or pH between 7.16-.31 in a venous sample. Exclusion Criteria: * age \<21 * Pregnant * Inmate/Prisoner * Contraindication for cuirass ventilator (open chest wound, flail chest, prior thoracic surgery) * Chest wall defect, neuromuscular disease or diaphragmatic paralysis. * BMI \>50
Where this trial is running
Columbia, Missouri
- University of Missouri Hospitals — Columbia, Missouri, United States (Recruiting)
Study contacts
- Principal investigator: Dennis Chairman, MD — University of Missouri-Columbia
- Study coordinator: Dennis B Chairman, MD
- Email: chairmand@umsystem.edu
- Phone: 573 884 1057
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.