Comparing Bipedal and Unipedal Exercises for Chronic Ankle Instability

When to Start Bipedal Exercises in Chronic Ankle Instability?

NA · Istanbul University - Cerrahpasa · NCT06244511

This study tests whether doing exercises on both feet or just one foot helps people with chronic ankle instability feel stronger and more stable.

Quick facts

PhaseNA
Study typeInterventional
Enrollment40 (estimated)
Ages18 Years to 50 Years
SexAll
SponsorIstanbul University - Cerrahpasa (other)
Locations1 site (Istanbul)
Trial IDNCT06244511 on ClinicalTrials.gov

What this trial studies

This study investigates the effectiveness of bipedal versus unipedal exercises in patients with chronic ankle instability (CAI). Participants diagnosed with CAI will be divided into two groups, one receiving early bipedal exercises and the other receiving late bipedal exercises. The aim is to assess improvements in proprioception, strength, and overall ankle stability through targeted therapeutic exercises. The study will include voluntary participants who meet specific inclusion criteria and will exclude those with certain pre-existing conditions.

Who should consider this trial

Good fit: Ideal candidates are individuals with documented unilateral chronic ankle instability who have experienced a prior ankle sprain at least six months ago.

Not a fit: Patients with a history of lower extremity surgery or other significant foot-ankle conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to more effective rehabilitation strategies for patients suffering from chronic ankle instability.

How similar studies have performed: Other studies have shown promising results with similar therapeutic exercise approaches for ankle instability, suggesting potential for success in this study.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* The documented unilateral ankle instability confirmed through clinical examinations (drawer test, talar tilt test) and MRI in cases requiring differential diagnosis.
* A history of an initial ankle sprain occurring at least 6 months ago.
* The presence of a recurrent sense of giving way that started at least 6 months ago and has been intermittently persistent.

Exclusion Criteria:

* Presence of a history of previous surgery in the lower extremity.
* Identification of organic and non-organic lesions such as cartilage injuries, periarticular tendon tears, and impingement syndromes.
* The existence of a fracture accompanying instability in the foot-ankle.
* Presence of congenital deformities in the foot-ankle.
* Diagnosis of talus osteochondral lesion.
* Diagnosis of ankle arthritis.
* Presence of medial ligament lesion.
* Existence of peripheral neuropathy.
* Presence of additional rheumatological diseases.
* Regular moderate-level exercise for at least 3 days a week in the last 6 months.

Where this trial is running

Istanbul

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Instability, Ankle, Proprioseptive exercise, Resistive exercise, Chronic ankle instability, Rehabilitation

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.