Clinical trial Recruiting at 1 site Interventional Ages 18 to 50

Comparing Bipedal and Unipedal Exercises for Chronic Ankle Instability

Official title: When to Start Bipedal Exercises in Chronic Ankle Instability?

Run by Istanbul University - Cerrahpasa · NCT06244511 · Data updated 2026-11-12

This study tests whether doing exercises on both feet or just one foot helps people with chronic ankle instability feel stronger and more stable.

Quick facts

Study typeInterventional
Ages18 Years to 50 Years
SexAll
Enrollment40 (estimated)
SponsorIstanbul University - Cerrahpasa
Academic / other
Locations1 site (Istanbul)
StatusRecruiting
StartedMarch 4, 2024
Main results expectedMarch 1, 2026
Study endsJuly 1, 2026
Registry record updatedMarch 24, 2025
Trial IDNCT06244511 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals with documented unilateral chronic ankle instability who have experienced a prior ankle sprain at least six months ago.

Probably not a fit

Patients with a history of lower extremity surgery or other significant foot-ankle conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of bipedal versus unipedal exercises in patients with chronic ankle instability (CAI). Participants diagnosed with CAI will be divided into two groups, one receiving early bipedal exercises and the other receiving late bipedal exercises. The aim is to assess improvements in proprioception, strength, and overall ankle stability through targeted therapeutic exercises. The study will include voluntary participants who meet specific inclusion criteria and will exclude those with certain pre-existing conditions.

Why it matters

Potential benefit: If successful, this study could lead to more effective rehabilitation strategies for patients suffering from chronic ankle instability.

How similar studies have gone: Other studies have shown promising results with similar therapeutic exercise approaches for ankle instability, suggesting potential for success in this study.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* The documented unilateral ankle instability confirmed through clinical examinations (drawer test, talar tilt test) and MRI in cases requiring differential diagnosis.
* A history of an initial ankle sprain occurring at least 6 months ago.
* The presence of a recurrent sense of giving way that started at least 6 months ago and has been intermittently persistent.

Exclusion Criteria:

* Presence of a history of previous surgery in the lower extremity.
* Identification of organic and non-organic lesions such as cartilage injuries, periarticular tendon tears, and impingement syndromes.
* The existence of a fracture accompanying instability in the foot-ankle.
* Presence of congenital deformities in the foot-ankle.
* Diagnosis of talus osteochondral lesion.
* Diagnosis of ankle arthritis.
* Presence of medial ligament lesion.
* Existence of peripheral neuropathy.
* Presence of additional rheumatological diseases.
* Regular moderate-level exercise for at least 3 days a week in the last 6 months.

Where it's running

  • Acibadem Mehmet Ali Aydinlar University
    Istanbul, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.