Comparing biomarker levels in dental pulp for different types of pulpitis
Comparison of IL-8, FGF-1 and VEGF Levels in Pulpal Tissue, GCF and Dentinal Fluid Samples of Healthy, Reversible and Irreversible Pulpitis Diagnosed Teeth
This study is testing the levels of certain markers in dental tissue from patients with healthy teeth and different types of pulpitis to see how they compare.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 14 Years to 60 Years |
| Sex | All |
| Sponsor | Kırıkkale University Academic / other |
| Locations | 1 site (Kırıkkale) |
| Trial ID | NCT06936553 on ClinicalTrials.gov |
What this trial studies
This observational study involves 50 patients diagnosed with healthy, reversible, and irreversible pulpitis. It aims to compare the levels of biomarkers IL-8, FGF-1, and VEGF in pulpal tissue, gingival crevicular fluid, and dentinal fluid samples collected from these patients. Non-invasive methods will be used to collect samples, followed by routine root canal treatment procedures. The collected samples will be analyzed using the ELISA test to determine the biomarker levels associated with different pulp conditions.
Who should consider this trial
Good fit: Ideal candidates include patients with healthy teeth, reversible pulpitis, or irreversible pulpitis as defined by specific clinical criteria.
Not a fit: Patients requiring antibiotic prophylaxis, those with diabetes or hematological diseases, or pregnant women may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of pulpitis and improve diagnostic accuracy for dental treatments.
How similar studies have performed: While similar studies have explored biomarker levels in pulpitis, this specific comparison of IL-8, FGF-1, and VEGF is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Control group: * Unrestored, caries-free vital teeth with healthy pulp * Orthodontically indicated teeth for extraction * wisdom teeth indicated for extraction in terms of oral hygiene * teeth that require root canal treatment for prosthetic purposes Reversible pulpitis group: * Teeth that react mildly to cold, hot, sour or sweet stimuli * Teeth with no history of spontaneous pain * Teeth that respond to cold test and electric pulp test within normal limits * Teeth that are not sensitive to chewing or percussion Irreversible pulpitis group: * Teeth with a history of continuous moderate or severe spontaneous pain * Teeth sensitive to percussion * Teeth without periapical pathology Exclusion Criteria: * Patients requiring antibiotic prophylaxis. * Patients with diabetes or haematological diseases. * Patients who have used antibiotics or anti-inflammatory drugs in the last three weeks. * Patients who are pregnant during treatment. * Patients with intense plaque and tartar on their teeth, redness and bleeding in the gums. * Patients with severe gingivitis, generalised periodontitis or periodontal pocket depth of more than 3 mm. * Patients with no response to pulp sensitivity tests, presence of sinus tract, presence of periapical pathology on radiography. * Teeth without pulp exposure after caries removal
Where this trial is running
Kırıkkale
- Kırıkkale University Faculty of Dentistry — Kırıkkale, Turkey (Recruiting)
Study contacts
- Study coordinator: Ali ERDEMİR
- Email: erdemirali@hotmail.com
- Phone: +905325650065
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.