Comparing biomarker levels in dental pulp for different types of pulpitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study involves 50 patients diagnosed with healthy, reversible, and irreversible pulpitis. It aims to compare the levels of biomarkers IL-8, FGF-1, and VEGF in pulpal tissue, gingival crevicular fluid, and dentinal fluid samples collected from these patients. Non-invasive methods will be used to collect samples, followed by routine root canal treatment procedures. The collected samples will be analyzed using the ELISA test to determine the biomarker levels associated with different pulp conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Control group:

* Unrestored, caries-free vital teeth with healthy pulp
* Orthodontically indicated teeth for extraction
* wisdom teeth indicated for extraction in terms of oral hygiene
* teeth that require root canal treatment for prosthetic purposes

Reversible pulpitis group:

* Teeth that react mildly to cold, hot, sour or sweet stimuli
* Teeth with no history of spontaneous pain
* Teeth that respond to cold test and electric pulp test within normal limits
* Teeth that are not sensitive to chewing or percussion

Irreversible pulpitis group:

* Teeth with a history of continuous moderate or severe spontaneous pain
* Teeth sensitive to percussion
* Teeth without periapical pathology

Exclusion Criteria:

* Patients requiring antibiotic prophylaxis.
* Patients with diabetes or haematological diseases.
* Patients who have used antibiotics or anti-inflammatory drugs in the last three weeks.
* Patients who are pregnant during treatment.
* Patients with intense plaque and tartar on their teeth, redness and bleeding in the gums.
* Patients with severe gingivitis, generalised periodontitis or periodontal pocket depth of more than 3 mm.
* Patients with no response to pulp sensitivity tests, presence of sinus tract, presence of periapical pathology on radiography.
* Teeth without pulp exposure after caries removal

Where it's running

• Kırıkkale University Faculty of Dentistry
  Kırıkkale, Turkey Recruiting

Study contacts

• Study coordinator: Ali ERDEMİR
• Email: erdemirali@hotmail.com
• Phone: +905325650065

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using pulpal blood biomarkers to predict success of vital pulp therapy in symptomatic teeth

  This trial will test whether measuring metabolic biomarkers in pulpal blood at the time of carious pulp exposure can help predict 12-month success of vital pulp treatment in people aged 16–50 with symptomatic deep caries.

  Recruiting University of Baghdad · Baghdad · NCT07452614

• Evaluating the success of vital pulp therapy methods for dental pulp exposure

  This study is testing different ways to treat exposed dental pulp to see which methods work best for adults with teeth that can be saved.

  Recruiting Semmelweis University · Budapest · NCT06844448

• Direct pulp capping for deep and extremely deep caries in mature molars with reversible pulpitis

  This study tests whether direct pulp capping works similarly for deep versus extremely deep caries in adult, mature mandibular molars with reversible pulpitis.

  Recruiting Postgraduate Institute of Dental Sciences Rohtak · Rohtak, Haryana · NCT07696702

• Buffered vs conventional local anesthesia for pain and anxiety during dental treatment in children with pulpitis

  This study tests whether buffered local anesthesia reduces pain and anxiety for school-aged children needing dental treatment for pulpitis.

  Recruiting Universidad Autonoma de San Luis Potosí · San Luis Potosí City, San Luis Potosí · NCT07638254

• Direct pulp capping in lower molars with side (proximal) versus top (occlusal) cavities: does the cavity location matter?

  This research will test whether direct pulp capping works as well for lower molars with side (proximal) cavities as for those with top (occlusal) cavities in people aged 15–40 who have reversible pulpitis.

  Recruiting Postgraduate Institute of Dental Sciences Rohtak · Rohtak, Haryana · NCT07578662

• Pulpotomy versus root canal treatment for extremely deep caries

  This study tests whether full pulpotomy works as well as root canal treatment for people aged 12 and older with extremely deep caries treated in a university dental clinic.

  Recruiting National University Hospital, Singapore · Singapore · NCT07242742

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.