Comparing biofilm on zirconia and titanium dental implants
Official title: Comparison of Biofilm Accumulation on the Surface of Zirconia Versus Titanium Implants. Randomized Controlled Pilot Clinical Trial
Run by Universidad Complutense de Madrid · NCT06075017 · Data updated 2026-11-12
This study is testing whether dental implants made of zirconia or titanium collect different amounts of biofilm and how that affects patient satisfaction over a year.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Universidad Complutense de Madrid Academic / other |
| Locations | 1 site (Madrid, Madrid) |
| Status | Recruiting |
| Started | December 1, 2027 |
| Main results expected | December 1, 2027 |
| Study ends | December 1, 2028 |
| Registry record updated | May 8, 2026 |
| Trial ID | NCT06075017 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults of both sexes who require a single dental implant and meet specific health criteria.
✕Probably not a fit
Patients with uncontrolled systemic diseases or those who cannot attend follow-up appointments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the differences in biofilm accumulation on zirconia versus titanium dental implants. A total of 30 single implants will be placed in different patients, with 15 made of zirconia and 15 made of titanium. The study will assess the amount and type of biofilm, along with other parameters such as bleeding on probing and patient satisfaction, at 3, 6, and 12 months post-implantation. Statistical analyses will be performed to determine the significance of the findings.
Why it matters
Potential benefit: If successful, this study could lead to improved dental implant materials that reduce the risk of infection.
How similar studies have gone: While there have been studies on dental implants, this specific comparison of biofilm on zirconia versus titanium is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients of both sexes of legal age. * Patients ASA I, II and III. * Subsequent to the placement of a single implant. * Patients who accept the surgery and sign the informed consent. Exclusion Criteria: * Pregnant or breastfeeding women * Patients who cannot attend follow-up appointments after surgery. * Patients with implants adjacent to the area to be treated. * Patients with uncontrolled periodontal pathology. * Systemic pathology that contraindicates the surgical procedure: hepatitis or other infectious diseases, oncological treatment, untreated or uncontrolled systemic pathology: diabetes mellitus, arterial hypertension, osteoporosis, heart failure, valvular heart disease, history of endocarditis, acute myocardial infarction less than 6 months ago, stroke less than 6 months ago, history of venous thromboembolism, arrhythmias, vitamin D deficiency, Parkinson's and Alzheimer's disease, dementia, psychiatric disorders, liver disease, COPD, chronic renal failure, immunosuppressed, autoimmune diseases, inflammatory bowel disease, digestive pathology, phosphocalcium metabolism diseases, hyper- or hypothyroidism, endocrinopathies, celiac disease, collagenosis, etc. * Pharmacological treatment with anticoagulants, antiaggregants, bisphosphonates, monoclonal antibodies, serotonin reuptake inhibitors, immunosuppressants, corticosteroids, antipsychotics.
Where it's running
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Complutense University of Madrid
Madrid, Madrid, Spain Recruiting
Study contacts
- Study coordinator: Jorge JC Cortés-Bretón, Dr.
- Email: jcortesb@ucm.es
- Phone: 913941966
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.