Comparing atenolol and metoprolol for reducing bleeding during nasal surgeries
Official title: Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries. A Randomized Clinical Trial
Run by Damanhour Teaching Hospital · NCT04914234 · Data updated 2026-11-12
This study is testing whether atenolol or metoprolol works better to reduce bleeding during nasal surgeries for patients needing general anesthesia.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 21 Years to 50 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Damanhour Teaching Hospital Government |
| Locations | 1 site (Damanhūr, El-Beheira) |
| Status | Recruiting |
| Started | December 1, 2025 |
| Main results expected | January 15, 2027 |
| Study ends | January 30, 2027 |
| Registry record updated | September 21, 2026 |
| Trial ID | NCT04914234 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 21 to 50 years with an ASA physical status of II or lower who are scheduled for nasal surgeries.
✕Probably not a fit
Patients with significant comorbidities, such as heart disease, chronic respiratory conditions, or those on anticoagulants, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the safety and efficacy of oral atenolol versus oral metoprolol as premedication for controlled hypotensive anesthesia in patients undergoing nasal surgeries. The study involves a prospective, randomized, double-blind design with 60 participants who are candidates for general anesthesia. Patients will be divided into two groups, with one receiving atenolol and the other metoprolol, to assess which medication better controls intraoperative bleeding and improves surgical outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved surgical outcomes and reduced complications during nasal surgeries by effectively managing intraoperative bleeding.
How similar studies have gone: Previous studies have explored the use of beta-blockers for controlled hypotension, indicating potential for success, but this specific comparison of atenolol and metoprolol is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status ≤ II * Age from 21 to 50 years Exclusion Criteria: * ASA physical status \> II * Age \< 21 years or \> 50 years * Pregnant women * Breastfeeding * Bronchial asthma * Chronic obstructive pulmonary disease * Diabetes Mellitus * Hypertension * Ischemic heart disease * Rheumatic heart disease * Heart failure * Heart block * Sick sinus syndrome * Sinus bradycardia * Chronic hypotension * Anemia (Hb \< 10 g/dl) * Renal or hepatic dysfunction * Central nervous system disease * Allergic fungal sinusitis * Patients on beta-blockers * Alcohol or drug abuse * Anticoagulation therapy, * Bleeding diathesis * Agents influencing autonomic nervous system * Allergy to the study drugs * Any contraindication of oral intake
Where it's running
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Damanhour Teaching Hospital
Damanhūr, El-Beheira, Egypt Recruiting
Study contacts
- Principal investigator: Ahmed M Shaat, MD — Damanhour Teaching Hospital
- Study coordinator: Ahmed M Shaat, MD
- Email: ahmedshaat99@gmail.com
- Phone: 00201223482709
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.