Comparing atenolol and metoprolol for reducing bleeding during nasal surgeries
Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries. A Randomized Clinical Trial
PHASE4 · Damanhour Teaching Hospital · NCT04914234
This study is testing whether atenolol or metoprolol works better to reduce bleeding during nasal surgeries for patients needing general anesthesia.
Quick facts
| Phase | PHASE4 |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 21 Years to 50 Years |
| Sex | All |
| Sponsor | Damanhour Teaching Hospital (other gov) |
| Locations | 1 site (Damanhūr, El-Beheira) |
| Trial ID | NCT04914234 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the safety and efficacy of oral atenolol versus oral metoprolol as premedication for controlled hypotensive anesthesia in patients undergoing nasal surgeries. The study involves a prospective, randomized, double-blind design with 60 participants who are candidates for general anesthesia. Patients will be divided into two groups, with one receiving atenolol and the other metoprolol, to assess which medication better controls intraoperative bleeding and improves surgical outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 21 to 50 years with an ASA physical status of II or lower who are scheduled for nasal surgeries.
Not a fit: Patients with significant comorbidities, such as heart disease, chronic respiratory conditions, or those on anticoagulants, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved surgical outcomes and reduced complications during nasal surgeries by effectively managing intraoperative bleeding.
How similar studies have performed: Previous studies have explored the use of beta-blockers for controlled hypotension, indicating potential for success, but this specific comparison of atenolol and metoprolol is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status ≤ II * Age from 21 to 50 years Exclusion Criteria: * ASA physical status \> II * Age \< 21 years or \> 50 years * Pregnant women * Breastfeeding * Bronchial asthma * Chronic obstructive pulmonary disease * Diabetes Mellitus * Hypertension * Ischemic heart disease * Rheumatic heart disease * Heart failure * Heart block * Sick sinus syndrome * Sinus bradycardia * Chronic hypotension * Anemia (Hb \< 10 g/dl) * Renal or hepatic dysfunction * Central nervous system disease * Allergic fungal sinusitis * Patients on beta-blockers * Alcohol or drug abuse * Anticoagulation therapy, * Bleeding diathesis * Agents influencing autonomic nervous system * Allergy to the study drugs * Any contraindication of oral intake
Where this trial is running
Damanhūr, El-Beheira
- Damanhour Teaching Hospital — Damanhūr, El-Beheira, Egypt (RECRUITING)
Study contacts
- Principal investigator: Ahmed M Shaat, MD — Damanhour Teaching Hospital
- Study coordinator: Ahmed M Shaat, MD
- Email: ahmedshaat99@gmail.com
- Phone: 00201223482709
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Hypotension Drug-Induced, atenolol, controlled hypotension, metoprolol, nasal surgery