Comparing anesthesia methods during brain tumor surgery and their effects on visual function
Comparison of the Effects of Total Intravenous Anesthesia and Balanced General Anesthesia on Flash Visual Evoked Potential Monitoring During Sellar Tumors Resection
This study is testing two different anesthesia methods during brain tumor surgery to see which one better protects patients' vision.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 84 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT04725032 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of two anesthesia methods—sevoflurane-propofol balanced anesthesia and propofol-based total intravenous anesthesia—on flash visual evoked potentials (FVEPs) during neurosurgery for sellar or parasellar tumors. The aim is to determine how these anesthesia techniques impact the amplitude and latency of FVEPs, which are crucial for monitoring visual function during surgery. By comparing these methods under similar bispectral index (BIS) levels, the study seeks to establish a more effective anesthesia approach that minimizes the risk of visual impairment during tumor resection. This research is particularly important given the high incidence of visual complications associated with these types of surgeries.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18-65 with ASA physical status I-III who are scheduled for elective resection of sellar or parasellar tumors.
Not a fit: Patients with preoperative visual acuity less than 0.3, significant obesity, uncontrolled chronic conditions, or cognitive disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved visual outcomes for patients undergoing surgery for sellar tumors.
How similar studies have performed: While total intravenous anesthesia has been widely accepted for FVEPs monitoring, this specific comparison of anesthesia methods is novel and has not been extensively tested in previous studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 18-65 years; 2. ASA I-III; 3. Elective sellar or parasellar tumors resection; 4. Informed written consent Exclusion Criteria: 1. Preoperative visual acuity\<0.3; 2. BMI\>30kg/cm2; 3. Uncontrolled hypertension, diabetes or cardiac diseases; 4. Preoperative cognitive disorders; 5. Sedatives, alcohol or analgesic addiction history; 6. Allergy to drugs of this study or contact allergy to Silicone products
Where this trial is running
Beijing, Beijing
- Beijing Tiantan Hospital, Capital Medical University — Beijing, Beijing, China (Recruiting)
Study contacts
- Principal investigator: Ruquan Han, M.D., Ph. D — Beijing Tiantan Hospital
- Study coordinator: Ruquan Han, M.D., Ph. D
- Email: ruquan.han@gmail.com
- Phone: +861059976660
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.