Comparing advanced single-fraction palliative radiotherapy techniques

Advanced Techniques for Single-fraction Palliative Radiotherapy Versus Standard Single Fraction Radiation

NA · Royal North Shore Hospital · NCT04658537

This study is testing if a new way of giving a single dose of radiation can help people with advanced cancer feel better and manage their pain longer than the usual method.

Quick facts

PhaseNA
Study typeInterventional
Enrollment100 (estimated)
SexAll
SponsorRoyal North Shore Hospital (other)
Drugs / interventionsradiation
Locations1 site (Saint Leonards, New South Wales)
Trial IDNCT04658537 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate whether advanced techniques for delivering a single fraction of palliative radiotherapy can provide longer-lasting benefits compared to standard single fraction treatment. Patients with metastatic cancer who are recommended for 8Gy of palliative radiation will be treated using intensity-modulated radiation therapy. The study will assess the impact on quality of life and symptom relief, particularly focusing on pain management and overall health outcomes. By utilizing advanced radiation techniques, the research seeks to improve the effectiveness of palliative care for patients with advanced disease.

Who should consider this trial

Good fit: Ideal candidates include patients with metastatic cancer who are recommended for single fraction palliative radiation therapy.

Not a fit: Patients who are recommended for multi-fraction palliative radiation therapy may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved pain relief and quality of life for patients with metastatic cancer receiving palliative radiotherapy.

How similar studies have performed: Other studies have shown promising results with advanced radiation techniques, suggesting potential for success in this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Metastatic cancer
* Recommended for 8Gy/1# palliative radiation
* Patients with spinal cord compression are eligible for enrolment

Exclusion Criteria:

* Unwilling or unable to give informed consent
* Patients who are recommended multi fraction palliative radiation

Where this trial is running

Saint Leonards, New South Wales

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Palliative Radiotherapy, Radiotherapy, Intensity-Modulated

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.