Comparing adrenaline nasal packing and xylometazoline nasal drops for nasal bleeding during intubation
Official title: Comparison of the Efficacy of Adrenaline Nasal Pack and Xylometazoline Nasal Drops in Decreasing Nasal Bleeding During Nasotracheal Intubation
Run by Shaheed Mohtarma Benazir Bhutto Institue of Trauma · NCT06801522 · Data updated 2026-11-12
This study is testing whether using xylometazoline nasal drops or adrenaline nasal packing works better to stop nosebleeds during intubation for certain facial surgeries.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Shaheed Mohtarma Benazir Bhutto Institue of Trauma Academic / other |
| Locations | 1 site (Karachi, Sindh) |
| Status | Recruiting |
| Started | December 1, 2024 |
| Main results expected | March 2025 |
| Study ends | May 2025 |
| Registry record updated | January 30, 2025 |
| Trial ID | NCT06801522 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18-60 undergoing elective oromaxillofacial surgery with an ASA classification of 1 or 2.
✕Probably not a fit
Patients with anticipated difficult airways, those on anticoagulant therapy, or with a history of nasal abnormalities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial aims to evaluate the effectiveness of xylometazoline nasal drops versus adrenaline nasal packing in reducing nasal bleeding during nasotracheal intubation for elective oromaxillofacial surgeries. Participants are randomly assigned to receive either 0.1% xylometazoline nasal drops or adrenaline-soaked nasal packing prior to intubation. The study includes thorough preoperative assessments and monitoring of vital signs. The goal is to determine which method is superior in managing nasal bleeding during the procedure.
Why it matters
Potential benefit: If successful, this study could lead to improved management of nasal bleeding during intubation, enhancing patient safety and surgical outcomes.
How similar studies have gone: While there have been studies on nasal bleeding management, this specific comparison of adrenaline nasal packing versus xylometazoline is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA 1 and 2 * Age group between 18-60 years * Mallampati score 1 and 2 * Either gender * Participants who undergo elective oromaxillofacial surgery Exclusion Criteria: * Lack of consent * Participants with anticipated difficult airway * Participants receiving anticoagulant therapy * History of nasal abnormality (nasal surgery, trauma, polyp, obstruction) * History of repeated epistaxis * History of uncontrolled hypertension, diabetes, pregnancy, and any other cardiac or cerebral events.
Where it's running
-
Shaheed Mohtarma Benazir Bhutto Institute of Trauma
Karachi, Sindh, Pakistan Recruiting
Study contacts
- Study coordinator: Dr Sidra Javed Consultant Anaesthetist, MBBS, FCPS, PAIN FELLOW
- Email: sidra_dow@yahoo.com
- Phone: +92333 2474831
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Left versus right nostril for nasotracheal intubation
This test checks whether using the left or right nostril causes more nosebleeds during nasotracheal intubation in adults having elective surgery.
-
Transseptal Suture vs Anterior Nasal Packing After Septoplasty
This study tests whether using a trans-septal suture or anterior nasal packing after septoplasty better reduces postoperative nasal pain and bleeding in adults with a deviated septum.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.