Comparing adrenaline nasal packing and xylometazoline nasal drops for nasal bleeding during intubation
Comparison of the Efficacy of Adrenaline Nasal Pack and Xylometazoline Nasal Drops in Decreasing Nasal Bleeding During Nasotracheal Intubation
This study is testing whether using xylometazoline nasal drops or adrenaline nasal packing works better to stop nosebleeds during intubation for certain facial surgeries.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Shaheed Mohtarma Benazir Bhutto Institue of Trauma Academic / other |
| Locations | 1 site (Karachi, Sindh) |
| Trial ID | NCT06801522 on ClinicalTrials.gov |
What this trial studies
This trial aims to evaluate the effectiveness of xylometazoline nasal drops versus adrenaline nasal packing in reducing nasal bleeding during nasotracheal intubation for elective oromaxillofacial surgeries. Participants are randomly assigned to receive either 0.1% xylometazoline nasal drops or adrenaline-soaked nasal packing prior to intubation. The study includes thorough preoperative assessments and monitoring of vital signs. The goal is to determine which method is superior in managing nasal bleeding during the procedure.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-60 undergoing elective oromaxillofacial surgery with an ASA classification of 1 or 2.
Not a fit: Patients with anticipated difficult airways, those on anticoagulant therapy, or with a history of nasal abnormalities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of nasal bleeding during intubation, enhancing patient safety and surgical outcomes.
How similar studies have performed: While there have been studies on nasal bleeding management, this specific comparison of adrenaline nasal packing versus xylometazoline is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA 1 and 2 * Age group between 18-60 years * Mallampati score 1 and 2 * Either gender * Participants who undergo elective oromaxillofacial surgery Exclusion Criteria: * Lack of consent * Participants with anticipated difficult airway * Participants receiving anticoagulant therapy * History of nasal abnormality (nasal surgery, trauma, polyp, obstruction) * History of repeated epistaxis * History of uncontrolled hypertension, diabetes, pregnancy, and any other cardiac or cerebral events.
Where this trial is running
Karachi, Sindh
- Shaheed Mohtarma Benazir Bhutto Institute of Trauma — Karachi, Sindh, Pakistan (Recruiting)
Study contacts
- Study coordinator: Dr Sidra Javed Consultant Anaesthetist, MBBS, FCPS, PAIN FELLOW
- Email: sidra_dow@yahoo.com
- Phone: +92333 2474831
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.