Comparing adjuvant chemoradiotherapy and chemotherapy for pancreatic cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial aims to compare the effectiveness of adjuvant chemoradiotherapy versus chemotherapy in patients with resected pancreatic cancer who are at high risk for disease progression. The study focuses on patients with specific risk factors such as lymph node metastases, R1 or R2 resection, or lymphovascular invasion. By evaluating patient outcomes, the trial seeks to clarify which treatment may offer better survival benefits. The study is conducted at Changhai Hospital in Shanghai, China.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18-75 years
* Pathologically confirmed pancreatic ductal adenocarcinoma
* Pathologically confirmed lymph node metastasis, R1 or R2 resection or lymphovascular invasion (one of the risk factors)
* No history of cancer treatment after surgical resection
* No disease progression confirmed by imaging examinations
* ECOG 0 to1 point
* No abnormality in blood routine test, liver and kidney function test and coagulation test (White blood cell count ≥4.0×10\^9/L, neutrophil count ≥2.0×10\^9, hemoglobin level ≥100g/L, platelet count ≥100×10\^9/L, ALT and AST level \< 2.5 times the upper limit of normal, total bilirubin and creatinine level within the normal, international normalized ratio \<2)

Exclusion Criteria:

* History of cancer treatment after surgical resection
* History of other cancers within 5 years
* Disease progression, including local pprogression or metastasis, confirmed by imaging examinations
* ECOG ≥2 points
* Significant abnormality in blood routine test, liver and kidney function test and coagulation test
* Active inflammatory bowel disease
* Gastrointestinal bleeding or perforation within 6 months
* Infections requiring antibiotics
* Heart or respirotory insufficiency
* Pregnant women or breastfeeding women

Where it's running

• Huojun Zhang
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Principal investigator: Huojun Zhang, M.D. — Changhai Hospital
• Study coordinator: Xiaofei Zhu
• Email: zhuxiaofei_zxf@163.com
• Phone: 86-021-31162222

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.