Comparing Adenosine and Verapamil for Treating Paroxysmal Supraventricular Tachycardia
Official title: Comparison of Verapamil With Adenosine After Vagal Maneuvers in Patients Presenting With Paroxysmal Supraventricular Tachycardia (pSVT), in a Tertiary Care Hospital of Lahore, Pakistan
Run by Rashid Latif Medical College · NCT06717685 · Data updated 2026-11-12
This study tests whether adenosine or verapamil works better to stop episodes of rapid heartbeats in people with paroxysmal supraventricular tachycardia.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 210 (estimated) |
| Sponsor | Rashid Latif Medical College Academic / other |
| Locations | 1 site (Lahore, Punjab Province) |
| Status | Recruiting |
| Started | October 28, 2024 |
| Main results expected | January 27, 2025 |
| Study ends | February 3, 2025 |
| Registry record updated | December 13, 2024 |
| Trial ID | NCT06717685 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients with stable PSVT who are conscious and able to provide consent.
✕Probably not a fit
Patients with unstable SVT, those unable to give consent, or those with certain cardiac conditions will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effectiveness of adenosine versus verapamil in treating patients with paroxysmal supraventricular tachycardia (PSVT). After performing a carotid sinus massage, patients will undergo either a conventional or modified Valsalva maneuver. If normal sinus rhythm is not restored, they will receive either adenosine or verapamil based on random assignment. The study aims to determine which medication is more effective in terminating PSVT episodes.
Why it matters
Potential benefit: If successful, this study could provide a more effective treatment option for patients experiencing PSVT, potentially reducing symptoms and improving quality of life.
How similar studies have gone: Previous studies have shown varying success rates for similar interventions, but this specific comparison of adenosine and verapamil in this context is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Stable SVT (not requiring cardioversion, fully conscious, maintaining systolic blood pressure of \>90mmHg) * Alert enough and able to give consent * Able to lie flat and non-painful legs during passive leg raising Exclusion Criteria: * Unstable SVT (Semiconscious, drowsy, breathless, systolic BP \<90mmHg) * Not able to give consent * Orthopnea causing inability to lie flat * Atrial fibrillation/atrial flutter * Recent MI (within last 7 days) * Ongoing ischemia as indicated by chest pain or ST segment depression/elevation in ECG * Aortic stenosis * All trimesters of pregnancy
Where it's running
-
Punjab Institute of Cardiology
Lahore, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Abdul Manan Shahid, FCPS
- Email: dr_hams79@yahoo.com
- Phone: +923336302776
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.