Comparing Adenosine and Verapamil for Treating Paroxysmal Supraventricular Tachycardia
Comparison of Verapamil With Adenosine After Vagal Maneuvers in Patients Presenting With Paroxysmal Supraventricular Tachycardia (pSVT), in a Tertiary Care Hospital of Lahore, Pakistan
PHASE3 · Rashid Latif Medical College · NCT06717685
This study tests whether adenosine or verapamil works better to stop episodes of rapid heartbeats in people with paroxysmal supraventricular tachycardia.
Quick facts
| Phase | PHASE3 |
|---|---|
| Study type | Interventional |
| Enrollment | 210 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Rashid Latif Medical College (other) |
| Locations | 1 site (Lahore, Punjab Province) |
| Trial ID | NCT06717685 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of adenosine versus verapamil in treating patients with paroxysmal supraventricular tachycardia (PSVT). After performing a carotid sinus massage, patients will undergo either a conventional or modified Valsalva maneuver. If normal sinus rhythm is not restored, they will receive either adenosine or verapamil based on random assignment. The study aims to determine which medication is more effective in terminating PSVT episodes.
Who should consider this trial
Good fit: Ideal candidates are patients with stable PSVT who are conscious and able to provide consent.
Not a fit: Patients with unstable SVT, those unable to give consent, or those with certain cardiac conditions will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more effective treatment option for patients experiencing PSVT, potentially reducing symptoms and improving quality of life.
How similar studies have performed: Previous studies have shown varying success rates for similar interventions, but this specific comparison of adenosine and verapamil in this context is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Stable SVT (not requiring cardioversion, fully conscious, maintaining systolic blood pressure of \>90mmHg) * Alert enough and able to give consent * Able to lie flat and non-painful legs during passive leg raising Exclusion Criteria: * Unstable SVT (Semiconscious, drowsy, breathless, systolic BP \<90mmHg) * Not able to give consent * Orthopnea causing inability to lie flat * Atrial fibrillation/atrial flutter * Recent MI (within last 7 days) * Ongoing ischemia as indicated by chest pain or ST segment depression/elevation in ECG * Aortic stenosis * All trimesters of pregnancy
Where this trial is running
Lahore, Punjab Province
- Punjab Institute of Cardiology — Lahore, Punjab Province, Pakistan (RECRUITING)
Study contacts
- Study coordinator: Abdul Manan Shahid, FCPS
- Email: dr_hams79@yahoo.com
- Phone: +923336302776
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Supraventricular Tachycardia, Ventricular, Tachycardia